Table 2

Univariate associations between early neonatal factors and the risk of chronic lung disease

		Respiratory pattern
Early neonatal factors		Low FiO₂	PD	EPPD	Row N
SNAP-II	≤19	16	42	61	622
	20–29	17	57	72	303
	≥30	31	74	76	260
Surfactant	Yes	17	55	70	1083
Surfactant	No	18	28	63	121
Hydrocortisone	Yes	20	70	69	89
Hydrocortisone	No	17	50	69	1115
Dexamethasone	Yes	33	75	61	12
Dexamethasone	No	17	52	70	1192
Analgesic	Yes	23	61	69	664
Analgesic	No	13	43	69	540
Sedation	Yes	26	54	59	174
Sedation	No	16	51	72	1030
Vitamin A	Yes	26	48	66	342
Vitamin A	No	15	53	71	862
Confirmed bactaeremia	Yes	20	66	65	73
Confirmed bactaeremia	No	17	51	70	1130
Confirmed tracheal infection	Yes	0	62	68	48
Confirmed tracheal infection	No	18	52	70	1147
Mechanical ventilation^* (day 7)	Yes	29	68	75	726
Mechanical ventilation^* (day 7)	No	14	30	42	477
Per cent CLD		17	52	69	52
Maximum column N		240	456	508	1204

The right-most column gives the maximum number of infants with the attribute listed in each row; any differences are due to missing data. All other data are the percentage of infants with CLD among those infants with the attribute listed in the two left columns and the respiratory patterns listed as column headings. For example, among infants with a SNAP-II score ≤19 who had the Low FiO₂ respiratory pattern, the prevalence of CLD was 16%.
↵* Mechanical ventilation includes conventional mechanical ventilation and high frequency ventilation.
CLD, chronic lung disease; EPPD, early and persistent pulmonary dysfunction; FiO₂, fraction of inspired oxygen; PD, pulmonary deterioration; SNAP-II, Score for Neonatal Acute Physiology.