Neurodevelopmental outcome at 2 years corrected age of 101 children birth weight ≤750 g
| By developmental test | By cohort | By gestational age | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| GMDS, n=49 (SD, min–max) | BSID, n=52 (SD, min–max) | GMDS vs BSID, p value | Total cohort*, n=101 (SD, min–max) | Cohort I*, n=45 (SD, min–max) | Cohort II*, n=56 (SD, min–max) | Cohort I vs II, p value | AGA*, n=45 (SD, min–max) | SGA*, n=56 (SD, min–max) | AGA vs SGA, p value | |
| Corrected absolute score | 96.45 (9.8, 80–127) | 93.50 (18.4, 54–128) | – | 94.93 (14.8, 54–128) | 97.63 (9.8, 80–127) | 92.76 (17.7, 54–128) | – | 97.97 (14.1, 54–127) | 92.49 (15.1, 58–128) | – |
| Z score corrected | −0.30 (0.8, −1.69 to 2.23) | −0.43 (1.2, −3.07 to 1.87) | 0.661 | −0.37 (1.0, −3.07 to 2.23) | −0.20 (0.8, −1.69 to 2.23) | −0.50 (1.2, −3.07 to 1.87) | 0.164 | −0.15 (1.0, −3.07 to 2.23) | −0.54 (1.0, −2.80 to 1.87) | 0.050 |
| Uncorrected absolute score | 86.08 (8.4, 72–113) | 83.85 (15.6, 54–114) | – | 84.93 (12.6, 54–114) | 86.90 (8.4, 72–113) | 83.35 (15.0, 54–114) | – | 86.56 (12.0, 54–113) | 83.62 (13.0, 54–114) | – |
| Z score uncorrected | −1.16 (0.7, −2.36 to 1.11) | −1.08 (1.0, −3.07 to 0.93) | 0.599 | −1.12 (0.9, −3.07 to 1.11) | −1.08 (0.7, −2.36 to 1.11) | −1.15 (1.0, −3.07 to 0.93) | 0.599 | −1.00 (0.9, −3.07 to 1.11) | −1.20 (0.9, −3.07 to 0.93) | 0.228 |
BSID-II: Bayley Scales of Infant Development-Second Edition, Mental Developmental Index (MDI); BSID-II standardisation mean (±SD)=100 (±15). Cohort I: 1996–2000; cohort II: 2001–2005. GMDS, Griffiths Mental Development Scales, Developmental Quotient, locomotor subscale excluded; GMDS standardisation mean (±SD)=100 (±12).
↵* GMDS DQ-LM and BSID-II MDI combined.
AGA, appropriate for gestational age, ≥p10; max, maximum raw score; min, minimum raw score; SGA, small for gestational age, <p10.