Susceptibility to antimicrobials used for treatment of neonatal septicaemia in bacteria from blood culture taken from neonates 2–28 days old, England and Wales, January 2006–March 2008
| Fluclox+gent | Amox+ctx | Amox+gent | Ctx | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Organism | Number | Tested | (Of total) (%) | S (%) | Tested | (Of total) (%) | S | Tested | (Of total) (%) | S (%) | Tested | (Of total) (%) | S (%) |
| Gram+ | 2811 | 1721 | (61) | 62 | 443 | (16) | 98 | 1143 | (41) | 97 | 115 | (4) | 79 |
| CoNS | 1569 | 1052 | (67) | 41 | 33 | (2) | 91 | 404 | (26) | 92 | 6 | (<1) | 17 |
| Staphylococcus aureus | 460 | 425 | (92) | 98 | 25 | (5) | 96 | 320 | (70) | 100 | 13 | (3) | 92 |
| Enterococcus spp. | 243 | 104 | (43) | 83 | 156 | (64) | 99 | 174 | (72) | 99 | 19 | (8) | 37 |
| GBS | 230 | 35 | (15) | 100 | 117 | (51) | 100 | 105 | (46) | 100 | 36 | (16) | 100 |
| Non-pyogenic streptococci* | 169 | 40 | (24) | 95 | 70 | (41) | 100 | 69 | (41) | 100 | 20 | (12) | 95 |
| Micrococcus sp. | 30 | 24 | (80) | 100 | 0 | (0) | NA | 22 | (73) | 100 | 0 | (0) | NA |
| Streptococcus pneumoniae | 25 | 9 | (36) | 100 | 15 | (60) | 100 | 10 | (40) | 100 | 7 | (28) | 100 |
| Other† | 85 | 32 | (38) | 81 | 27 | (32) | 81 | 39 | (46) | 100 | 14 | (16) | 64 |
| Gram− | 671 | 481 | (72) | 96 | 304 | (45) | 85 | 506 | (75) | 93 | 250 | (37) | 77 |
| Enterobacteriaceae‡ | 311 | 224 | (72) | 94 | 122 | (39) | 75 | 222 | (71) | 95 | 122 | (39) | 69 |
| Escherichia coli | 236 | 181 | (77) | 98 | 143 | (61) | 98 | 195 | (83) | 93 | 104 | (44) | 95 |
| Pseudomonas spp. | 66 | 54 | (82) | 94 | 13 | (20) | 46 | 55 | (83) | 95 | 9 | (14) | 11 |
| Other§ | 58 | 22 | (38) | 95 | 26 | (45) | 96 | 34 | (59) | 82 | 15 | (26) | 60 |
| Total excluding CoNS | 1913 | 1150 | (60) | 95 | 714 | (37) | 93 | 1245 | (65) | 97 | 359 | (19) | 79 |
| Total | 3482 | 2202 | (63) | 69 | 747 | (21) | 93 | 1649 | (47) | 96 | 365 | (10) | 78 |
↵* S viridans, S mitis, S salivarius, S oralis, S sanguinis group, S bovis, S milleri, S anginosus, S constellatus, S gordonii, S intermedius, Aerococcus spp.
↵† Bacillus sp., β-haemolytic streptococci, diphtheroids, Streptococcus group A, Streptococcus group D, Listeria monocytogenes, Lactococcus spp., Clostridium perfringens, Lactobacillus sp., Propionibacterium sp., Bacillus cereus, Gemella haemolysins, Stomatococcus mucilaginosus, Listeria sp., Micrococcus luteus, S anaerobic, Streptococcus group G.
↵‡ Enterobacter spp., Klebsiella spp., coliform, Serratia spp., Citrobacter spp., Proteus spp., Morganella spp., Kluyvera sp., Salmonella monschaui, Yersinia enterocolitica.
↵§ Acinetobacter spp., Stenotrophomonas maltophilia, Neisseria meningitidis, Haemophilus influenzae, Moraxella spp., Neisseria sp., Haemophilus parainfluenzae, Ochrobactrum anthropi, Achromobacter sp., Alcaligenes faecalis, Bordetella bronchiseptica, Burkholderia cepacia, Haemophilus sp., Pasteurella multocida, Roseomonas sp., Sphingomonas paucimobilis.
Amox, amoxicillin; CoNS, coagulase-negative staphylococci; ctx, cefotaxime; Fluclox, flucloxacillin; GBS, group B streptococcus; gent, gentamicin; Pen, penicillin; S, susceptibility.