Susceptibility to antimicrobials used for treatment of neonatal septicaemia in bacteria from blood culture taken from neonates less than 48 h old, England and Wales, January 2006–March 2008
| Pen+gent | Amox+ctx | Amox+pen | Ctx | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Organism | Number | Tested | (Of total) (%) | S (%) | Tested | (Of total) (%) | S (%) | Tested | (Of total) (%) | S (%) | Tested | (Of total) (%) | S (%) |
| Gram+ | 1246 | 927 | (74) | 93 | 426 | (34) | 100 | 752 | (60) | 97 | 92 | (7) | 96 |
| GBS | 477 | 371 | (78) | 99 | 247 | (52) | 100 | 402 | (84) | 100 | 56 | (12) | 100 |
| CoNS | 326 | 219 | (67) | 80 | 5 | (2) | 100 | 67 | (21) | 78 | 2 | (1) | 100 |
| Non-pyogenic streptococci* | 142 | 120 | (85) | 87 | 78 | (55) | 100 | 111 | (78) | 100 | 23 | (16) | 91 |
| Staphylococcus aureus | 75 | 60 | (80) | 100 | 1 | (1) | 100 | 11 | (15) | 73 | 0 | (0) | NA |
| Enterococcus spp. | 49 | 20 | (41) | 90 | 40 | (82) | 100 | 41 | (84) | 98 | 2 | (4) | 50 |
| Micrococcus sp. | 35 | 30 | (86) | 100 | 1 | (3) | 100 | 20 | (57) | 100 | 0 | (0) | NA |
| Streptococcus pneumoniae | 32 | 28 | (88) | 100 | 17 | (53) | 100 | 28 | (88) | 100 | 4 | (13) | 100 |
| Other† | 110 | 79 | (72) | 99 | 37 | (34) | 100 | 72 | (65) | 99 | 5 | (5) | 80 |
| Gram− | 270 | 177 | (66) | 99 | 164 | (61) | 99 | 114 | (42) | 99 | 104 | (39) | 97 |
| Escherichia coli | 137 | 119 | (87) | 98 | 98 | (72) | 100 | 69 | (50) | 99 | 66 | (48) | 100 |
| Enterobacteriaceae‡ | 35 | 28 | (80) | 100 | 16 | (46) | 94 | 4 | (11) | 100 | 15 | (43) | 87 |
| Haemophilus influenzae | 34 | 1 | (3) | 100 | 23 | (68) | 100 | 19 | (56) | 100 | 11 | (32) | 100 |
| Other§ | 64 | 29 | (45) | 100 | 27 | (42) | 96 | 22 | (34) | 100 | 12 | (19) | 92 |
| Total excluding CoNS | 1190 | 885 | (74) | 97 | 585 | (49) | 100 | 799 | (67) | 99 | 194 | (16) | 96 |
| Total | 1516 | 1104 | (73) | 94 | 590 | (39) | 100 | 866 | (57) | 98 | 196 | (13) | 96 |
↵* S viridans, S mitis, S oralis, S salivarius, S sanguinis group, S intermedius, S milleri, S anginosus, S acidominimus, S gordonii, Abiotrophia spp., Aerococcus spp.
↵† Diphtheroids, β-haemolytic streptococci, Listeria monocytogenes, Bacillus sp., Streptococcus group A, Propionibacterium sp., Streptococcus group G, Streptococcus group C, Streptococcus group D, Bacillus other named, Bacteroides spp., Lactococcus cremoris, Listeria sp., Streptococcus group D, Eubacterium sp., Gardnerella vaginalis, S anaerobic, S dysgalactiae, S equisimilis.
↵‡ Klebsiella spp., coliform, Enterobacter spp., Morganella spp., Kluyvera sp., Citrobacter spp., Pantoea sp., Proteus spp., Salmonella paratyphi, Serratia spp.
↵§ Pseudomonas spp., Acinetobacter spp., Haemophilus parainfluenzae, Haemophilus sp., Moraxella spp., Stenotrophomonas maltophilia, Bacteroides spp., Neisseria sp., Sphingomonas paucimobilis, Aeromonas spp., Peptostreptococcus spp., Burkholderia cepaci, Oligella urethralis, Roseomonas sp., Weeksella virosa.
Amox, amoxicillin; CoNS, coagulase-negative staphylococci; ctx, cefotaxime; GBS, group B streptococcus; gent, gentamicin; Pen, penicillin; S, susceptibility.