Table 4

Comparison of survival and disability outcomes in various geographical cohorts in babies born at less than 26 weeks

NameLocationYear of birthAge at follow-upDefinition of severe disabilitySurvival to follow-up*Severe disability at follow-up*Severe disability at follow-up
TNSTrent, United Kingdom1991–199324 monthsAudit commission standards59/249 (23.6%)19/249 (8%)19/59 (32%)
EPICureUnited Kingdom and Ireland199530 monthsOne that was likely to put the child in need of physical assistance to perform daily activities308/808 (38%)73/808 (9 %)73/308 (24%)
The Leiden follow-up projectThree health regions in The Netherlands1996–199724 monthsEither of abnormal muscle tone and reflex or MDI <68 or PDI <6811/23 (48%)6/23 (26%)6/11 (54%)
Victoria Infant Collaborative Study GroupVictoria, Australia199724 monthsCerebral palsy (unlikely ever to walk), blindness and development quotient <−3 SD on MDI of Bayley scales of infant development62/90 (69%)11/90 (12%)11/62 (18%)
EPIBELFlanders, Belgium1999–200136 monthsEither of neurologic abnormality (neuromotor, sensory and communicative functioning and non-febrile seizures) or MDI or PDI <7041/84 (49%)13/84 (15.4%)13/41 (32%)
TNSTrent, United Kingdom2001–2003Oxford minimum dataset standards103/230 (45%)48/230 (21%)48/103 (47%)
Victoria Infant Collaborative Study GroupVictoria, Australia200524 monthsSevere developmental delay was characterised by a score on either scale <−3 SD of Bayley Scales of Infant and Toddler DevelopmentConcludes that level of disability has improved as compared to 1997 cohort in babies born at less that 28 weeks' gestation.
  • * Out of babies admitted for neonatal intensive care.

  • Out of survivors to follow-up.

  • Number of live born babies offered intensive care and gestation-specific disability outcomes not available in paper.

  • EPIBEL, extremely preterm infants in Belgium study group; MDI, mental development index; PDI, psychomotor development index.