Outcomes for subgroup of infants under 850 g
| Outcome | TPN with heparin (n=26) | TPN without heparin (n=28) | RR (95% CI) | Risk difference (95% CI) | p Value |
|---|---|---|---|---|---|
| Any CRS (definite, probable or possible) | 6 | 12 | 0.54 (0.23 to 1.17) | −0.2 (−0.43 to 0.06) | 0.12 |
| Definite or probable CRS | 4 | 6 | 0.72 (0.24 to 2.12) | −0.06 (−0.27 to 0.16) | 0.57 |
| Definite CRS | 0 | 4 | −0.143 (−0.32 to −0.003) | 0.045 | |
| Probable CRS | 4 | 2 | 2.15 (0.5 to 9.53) | 0.08 (−0.1 to 0.28) | 0.34 |
| Possible CRS | 2 | 6 | 0.36 (0.09 to 1.4) | −0.14(−0.34 to 0.06) | 0.16 |
| Occlusion | 0 | 0 | |||
| Extravasation | 2 | 4 | 0.54 (0.12 to 2.31) | −0.07 (−0.25 to 0.12) | 0.44 |
| Elective catheter removal | 15 | 16 | 1.01 (0.63 to 1.61) | 0.01 (−0.25 to 0.26) | 0.97 |
| Death during trial | 0 | 1 | |||
| IVH progression (yes/yes+no+unknown) | 0/26 | 4/28 | −0.14 (−0.32 to −0.003) | 0.045 | |
| IVH progression (yes/yes+no) | 0/26 | 4/27 | −0.15 (−0.33 to −0.01) | 0.04 |
CRS, catheter-related sepsis; IVH, intraventricular haemorrhage; TPN, total parenteral nutrition.