Table 2

Univariate analysis of selected precooling attributes for prediction of death in infants with significant HIE despite therapeutic hypothermia

VariablesOdds ratio (95% CI)p Value
Variables predicting neonatal death
 5 min Apgar score of zero13.6 (3.0 to 60.6)0.001
 10 min Apgar score of zero32.6 (6.4 to 166.5)<0.001
 1st blood gas pH of <6.7 within 60 min5.6 (1.3 to 24.1)0.031
 1st blood gas base deficit of >18.5 mmol/l within 60 min3.5 (0.7 to 17.6)0.175
 1st blood gas base deficit of >22 mmol/l within 60 min5.3 (1.2 to 22.2)0.029
 Presence of clinical seizure before start of cooling2.0 (0.5 to 7.7)0.331
 Flaccidity1.2 (0.3 to 5.2)1.000
 Decerebrate posturing1.3 (0.3 to 5.8)0.703
 Absent spontaneous activity5.3 (1.2 to 22.2)0.029
 Absent or weak suck/gag reflexes1.2 (1.1 to 1.3)0.203
 Abruption1.7 (0.4 to 7.4)0.435
 Cord accident or/and ruptured uterus2.2 (0.5 to 9.9)0.371
 MSAF with fetal bradycardia0.4 (0.1 to 2.1)0.483
Variables predicting death during follow-up to at least 9 months
 5 min Apgar score of zero15.7 (4.0 to 61.9)<0.001
 10 min Apgar score of zero51.7 (9.9 to 269.5)<0.001
 1st blood gas pH of <6.7 within 60 min5.8 (1.5 to 22.7)0.017
 1st blood gas base deficit of >18.5 within 60 min1.9 (0.5 to 6.7)0.375
 1st blood gas base deficit of >22 within 60 min3.6 (1.1 to 12.3)0.035
 Presence of clinical seizure before start of cooling2.2 (0.7 to 7.5)0.232
 Flaccidity1.2 (0.3 to 4.3)1.000
 Decerebrate posturing1.4 (0.4 to 5.2)0.727
 Absent spontaneous activity5.5 (1.5 to 19.7)0.010
 Absent or weak suck/gag reflexes1.2 (1.1 to 1.4)0.114
 Abruption1.1 (0.3 to 4.6)1.000
 Cord accident or/and ruptured uterus1.5 (0.3 to 6.2)0.692
 MSAF with fetal bradycardia0.5 (0.1 to 1.9)0.366
  • HIE, hypoxic-ischaemic encephalopathy; MSAF, meconium stained amniotic fluid.