Table 3

Evolution in very preterm mortality and morbidity between 1997 and 2003

	1997 (%)	2003 (%)
		N=488	N=580	p Value^*	OR_adj^† (95% CI)
Babies 24–31 weeks
In-hospital death^†	19.1	14.8	0.065	0.66 (0.46 to 0.95)
In-hospital death^†	N=470	N=551
Diagnosis of IVH III+IV^‡	11.3	4.1	<0.001	0.27 (0.15 to 0.47)
Diagnosis of PVL^‡	7.3	6.3	NS	0.83 (0.50 to 1.37)
Diagnosis of PVL^‡		N=395	N=494
BPD^§	14.4	15.3	NS	0.85 (0.56 to 1.29)
Babies 24–27 weeks	N=137	N=159
In-hospital death^†	43.3	33.3	0.11	0.68 (0.40 to 1.14)
In-hospital death^†	N=122	N=138
Diagnosis of IVH III+IV^‡	29.7	11.3	<0.001	0.27 (0.13 to 0.55)
Diagnosis of PVL^‡	10.2	8.3	NS	0.81 (0.33 to 2.0)
	N=79	N=106
BPD^§	40.5	30.1	0.14	0.55 (0.27 to 1.10)
Babies 28+ weeks	N=351	N=421
In-hospital death^‡	10.0	7.8	NS	0.66 (0.39 to 1.11)
In-hospital death^‡	N=348	N=413
Diagnosis of IVH III+IV^§	4.8	1.7	0.016	0.29 (0.11 to 0.74)
Diagnosis of PVL^§	6.3	5.6	NS	0.82 (0.44 to 1.53)
Diagnosis of PVL^§	N=316	N=388
BPD	7.9	11.3	0.14	1.11 (0.63 to 1.93)

↵* χ² test for unadjusted proportions.
↵† Adjusted for gestational age, birth weight, pregnancy complications, sex, multiple pregnancy and maternal age.
↵‡ Computed on all live births.
↵§ Computed for all babies admitted to NICU—19 observations missing for EPIPAGE, 9 for MOSAIC.
¶ Computed for babies discharged home 0 missing observations for EPIPAGE, 9 for MOSAIC.
BPD, bronchopulmonary dysplasia; IVH, intraventricular haemorrhage; PVL, periventricular leucomalacia.