Table 1 Infant demographics, risk factors and incidence of Candida sepsis before and after the implementation of the antifungal prophylaxis guideline
Before guideline implementationAfter guideline implementationp Value
Number of medical records available110102
Gestational age (weeks), median (range)28 (24–36)28 (23–34)>0.9
Birth weight (g), median (range)1040 (380–1495)980 (429–1490)0.3
Number eligible for prophylaxis, n/N (%)33/110 (31)31/102 (30)>0.9
Cephalosporin use, n/N (%)18/110 (16)14/102 (14)>0.9
Antibiotic >10 days, n/N (%)23/110 (21)19/102 (19)>0.9
Fungal colonisation + central venous catheter, n/N (%)6/110 (6)6/102 (6)>0.9
Culture proven Candida sepsis in eligible babies6/330/310.03
Culture proven and probable Candida sepsis in eligible babies6/331/310.1
Total died7/333/310.2
Died Candida sepsis4/330/310.11