Spontaneous PDA closure (n = 35) | PDA no IVH III/IV or death (n = 25) | PDA with IVH III/IV ± death (n = 20) | p Value 1 | p Value 2 | |
PDA diameter (mm) | 0 (0–0) | 2.35 (1.8–2.9) | 2.30 (1.5–3.1) | <0.001 | 0.88 |
LA:Ao ratio | 1.42 (1.2–1.6) | 1.94 (1.8–2.3) | 1.96 (1.8–2.6) | <0.001 | 0.91 |
RVO (ml/kg/min) | 243 (214–301) | 232 (137–293) | 248 (140–257) | 0.84 | 0.69 |
LVO (ml/kg/min) | 172 (137–204) | 248 (188–304) | 230 (132–247) | <0.001 | 0.45 |
DAo EDV (m/s) | 0.07 (0.05–0.10) | −0.02 (−0.14–0.08) | −0.06 (−0.15–0.00) | 0.003 | 0.47 |
NTpBNP (pmol/l) | 740 (355–2884) | 5121 (2324–6202) | 9282 (5013–16911) | <0.001 | 0.008 |
cTnT (μg/l) | 0.13 (0.08–0.23) | 0.25 (0.15–0.65) | 0.66 (0.39–2.30) | <0.001 | 0.027 |
Values are represented as medians (IQR). p Value 1 represents the difference between the spontaneous PDA closure group and the entire PDA group. p Value 2 represents the differences between the PDA subgroups. There was no difference in the echocardiographic parameters between the PDA subgroups. NTpBNP and cTnT were significantly higher in infants with a PDA and complications than infants with a PDA and no complications.
cTnT, cardiac troponin T; DAo EDV, descending aortic end-diastolic velocity; IQR, interquartile range; IVH, intraventricular haemorrhage; LA:Ao, left atrial to aortic ratio; LVO, left ventricular output; NTpBNP, N-terminal-pro-B type natriuretic peptide; PDA, patent ductus arteriosus; RVO, right ventricular output.