Comparison of development between the donor breast milk and formula groups
| Outcome and studies | Sole diet comparison | Supplementary diet comparison | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Donor breast milk | Formula | RR (95% CI) | p value | Donor breast milk | Formula | RR (95% CI) | p value | |||||||||
| No. | n (%) | No. | n (%) | No. | n (%) | No. | n (%) | |||||||||
| Neurological status impaired at 9 months | ||||||||||||||||
| Lucas et al17 | 66 | 4 (6.1%) | 56 | 9 (16.1%) | 0.38 (0.12 to 1.16) | p = 0.074 | 140 | 15 (10.7%) | 138 | 15 (10.9%) | 0.99 (0.50 to 1.94) | p = 0.97 | ||||
| Neurological status impaired at 18 months | ||||||||||||||||
| Lucas et al17 | 66 | 4 (6.1%) | 56 | 7 (12.5%) | 0.48 (0.15 to 1.57) | p = 0.22 | 140 | 11 (7.9%) | 138 | 10 (7.2%) | 1.08 (0.48 to 2.47) | p = 0.85 | ||||
| N | Mean | SD | N | Mean | SD | MD | N | Mean | SD | N | Mean | SD | MD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MD, mean difference; No., total, n, number of cases. | ||||||||||||||||
| RR<1 favours donor breast milk; MD<0 favours donor breast milk. | ||||||||||||||||
| Development quotient at 9 months (Knobloch) | ||||||||||||||||
| Lucas et al17 | 62 | 97.2 | 8.5 | 48 | 98.2 | 11.0 | −1.0 (−4.7 to 2.7) | p = 0.59 | 133 | 98.2 | 10.1 | 126 | 101.2 | 10.5 | −3.0 (−5.52 to −0.48) | p = 0.020 |
| Mental developmental index at 18 months (Bayley) | ||||||||||||||||
| Lucas et al19 | 62 | 94.8 | 16.5 | 52 | 95.3 | 19.5 | −0.5 (−7.1 to 6.2) | p = 0.88 | 134 | 102.2 | 19.7 | 139 | 103.8 | 20.0 | −1.6 (−6.33 to 3.13) | p = 0.51 |
| Psychomotor developmental index at 18 months (Bayley) | ||||||||||||||||
| Lucas et al19 | 62 | 93.0 | 14.2 | 52 | 94.2 | 15.9 | −1.2 (−6.8 to 4.4) | p = 0.67 | 134 | 95.5 | 15.0 | 139 | 94.5 | 16.5 | 1.0 (−2.76 to 4.76) | p = 0.60 |