Van der Elst et al10 | Not clearly stated | 49 | No distinction made between symptomatic/asymptomatic. All symptoms considered minor | PCV of 65% | PCV to <60% | Umbilical vein catheter. FFP | BNBAS and neurological assessment of Prechtl at 10 days | Neurological, developmental assessment at 8 months (similar to the Griffith development score) |
Goldberg et al11 | Not clearly stated | 20 | No distinction made between symptomatic and asymptomatic | Venous PCV ⩾64% and hyperviscous. Antecubital vein | PCV to 50% | Umbilical vein catheter. FFP | BNBAS at 8 h, 24 h, 72 h, and 2 weeks | BSID and neurological assessment at 8 months |
Black et al12 | “Term” | 93 | No distinction made between symptomatic and asymptomatic | Venous PCV 65% and hyperviscous. Antecubital vein | PCV to 50% | Umbilical vein catheter. FFP | Neonatal symptoms | BSID and neurological assessment at 1 and 2 years. Slosson IQ and WRAT test at 7 years |
Bada et al13 | Not clearly stated | 28 | Only asymptomatic patients were randomised | Radial artery PCV ⩾63% | PCV to 55% | Route not stated. Plasmanate | Cerebral artery Doppler measurements | BSID or Stanford Binet and neurological assessment at 30 months |
Ratrisawadi et al14 | Not clearly stated | 105 | Only asymptomatic patients were randomised | Central venous PCV 65% or more | PCV to 60% | Route not stated | None | Gasel development at 1.5–2 years |