Table 6

 Feeding details in studies of erythromycin as a prokinetic agent in preterm neonates

StudyTypeMethodIncrementsDefinition of feed intolerance
*Study presented as abstract,30,31 paper not published yet.
EBM, Expressed breast milk; NG, nasogastric.
Patole et al24EBM/preterm formulaIntragastric 1–2 hourly bolus feeds; prone, head elevation positionMaximum 24 ml/kg/dayBile stained gastric residuals, abdominal distension, vomiting
Stenson et al25EBMIntragastric hourly bolus feeds1 ml until full feedsNot defined clearly; net enteral balance was assessed: NG feed volume minus the NG aspirate volume
Oei & Lui26EBM/formulaIntragastric 2 hourly bolus feeds⩽30 ml/kg/dayAbdominal distension; repeated large aspirates; gastric residuals >30% of previous 6 hours of feeds
Ng et al27EBM/preterm formulaIntragastric hourly bolus feeds0.5–1 ml/h/dayVomiting >twice in 24 h; gastric residuals >50% of previous 4 h on two occasions within a day; repeated regurgitations; suspected NEC or aspiration pneumonia
ElHennawy et al29EBM/preterm formulaIntragastric bolus feeds20 ml/kg/daySevere abdominal distension (>15% of baseline abdominal girth); gastric residuals >25% of fed volume; frank blood in stools
Ng et al28EBM/preterm milk formulaIntragastric bolus feeds; continuous feeds if 50% of bolus feeds not tolerated 2 weeks after starting feeds; prone, head elevated position<10 ml/kg/day during first week <20 ml/kg/day laterVomiting >twice in 24 h; gastric residuals >25% of preceding 4 h on two occasions; repeated regurgitations; suspected NEC or aspiration pneumonia
*Cairns et al30,31Not availableNot availableNot availableNot available