Short term outcome of studied infants
| Allopurinol (n = 17) | Vehicle (n = 15) | |
|---|---|---|
| *One missing in vehicle group but postmortem MRI. | ||
| †Died. | ||
| aEEG, Amplitude integrated electroencephalogram; MRI, magnetic resonance imaging. | ||
| Recovery aEEG to normal pattern within 24 h | 7 (3†) | 7 (2†) |
| No recovery of aEEG to normal pattern | 10 (10†) | 8 (8†) |
| Seizure activity | ||
| None | 1 (6%) | 1 (7%) |
| Single or repetitive seizures | 8 (47%) | 9 (60%) |
| Status epilepticus | 8 (47%) | 5 (33%) |
| Cranial ultrasonography (n = 31)* | ||
| Normal | 2 (12%) | 3 (20%) |
| Increased echogenicity of basal ganglia | 6 (35%) | 7 (47%) |
| Increased echogenicity of (sub)cortical region | 4 (24%) | 0 (0%) |
| Increased echogenicity in both regions | 5 (29%) | 4 (27%) |
| Cranial MRI (n = 12) | ||
| Normal | 1 (6%) | 1 (7%) |
| Basal ganglia abnormalities | 2 (12%) | 1 (7%) |
| (Sub)cortical abnormalities | 2 (12%) | 2 (13%) |
| Abnormalities in both regions | 1 (6%) | 2 (13%) |
| Mortality | 13 (76%) | 10 (67%) |