Major morbidity and death
| 20 mg/kg (n = 113) | 5 mg/kg (n = 121) | RR (95% CI) | p Value | |
|---|---|---|---|---|
| Values are number (%). | ||||
| *Major cerebral abnormality at 6 weeks defined as one or more of the following: cerebral cystic formation (porencephalic cysts or periventricular leucomalacia or encephaloclastic porencephaly) or hydrocephalus. | ||||
| †Oxygen requirement at 28 days of postmenstrual age in survivors at hospital discharge. ‡Oxygen requirement at 36 weeks of postmenstrual age in survivors at hospital discharge. | ||||
| Proven infection | 52 (46) | 60 (50) | 0.93 (0.71 to 1.21) | 0.59 |
| Necrotising enterocolitis | 0 | 5 (4) | ||
| Intraventricular haemorrhage | ||||
| Data available | n = 112 | n = 121 | ||
| Total | 33 (30) | 34 (28) | 1.04 (0.68, 1.58) | 0.86 |
| Grades 3 or 4 | 5 | 1 | 0.11 | |
| Major cerebral abnormalities at 6 weeks of age* | 7 (7) | 10 (11) | 0.64 (0.26 to 1.61) | 0.34 |
| Data available | n = 97 | n = 89 | ||
| Retinopathy of prematurity | 21 (23) | 34 (33) | 0.68 (0.43 to 1.09) | 0.11 |
| Stage 3 and 4 | 3 | 8 | 0.42 (0.11 to 1.52) | 0.22 |
| Data available | n = 92 | n = 102 | ||
| Pulmonary air leak | 5 (4) | 7 (6) | 0.77 (0.25 to 2.34) | 0.64 |
| Chronic lung disease | ||||
| Chronic lung disease, 28 days† | 64 (66) | 80 (74) | 0.89 (0.74 to 1.07) | 0.22 |
| Data available | n = 97 | n = 108 | ||
| Chronic lung disease, 36 weeks‡ | 33 (34) | 51 (48) | 0.72 (0.51 to 1.01) | 0.06 |
| Data available | n = 96 | n = 107 | ||
| Death before hospital discharge | 5 (4) | 7 (6) | 0.77 (0.25 to 2.34) | 0.64 |