20 mg/kg (n = 113) | 5 mg/kg (n = 121) | p Value | ||
---|---|---|---|---|
*Values are number (%). | ||||
†Values are mean (SD). | ||||
‡Values are median (interquartile range). | ||||
¶Data available for 116 infants in the 5 mg/kg group, and 110 infants in the 20 mg/kg group. | ||||
Tachycardia | 4 | 1 | ||
Caffeine withheld | 3 | 0 | ||
Jitteriness | 2 | 2 | ||
Caffeine withheld | 0 | 0 | ||
Total in whom caffeine was withheld* | 9 (8) | 5 (4) | 0.24 | |
Feed intolerance* | 40 (35) | 37 (31) | 0.44 | |
Total parenteral nutrition (days)† | 14.3 (8.26) | 15.5 (10.8) | 0.80 | |
Weight gain (g/kg/day)‡ | 12.2 (6.5–15.2) | 12.6 (9.2–15.2) | 0.35 | |
Time to regain birthweight (days)†¶ | 14.8 (5.3) | 12.9 (5.0) | <0.01 |