Comparison of the clinical characteristics, respiratory indices, and outcomes of infants with chronic lung disease (CLD) or who had died (group 1) and those without CLD (group 2)
| Group 1 (n = 45) | Group 2 (n = 92) | |
|---|---|---|
| Results are median (interquartile range) or number (%). | ||
| **p<0.01 and *p<0.05 compared with group 1. | ||
| CRIB, Clinical risk index for babies; OI, oxygenation index; A-aDo2, alveolar-arterial oxygen gradient; CPAP, continuous positive airway pressure; HFOV, high frequency oscillatory ventilation; IPPV, intermittent positive pressure ventilation; PIP, peak inspiratory pressure; Paw, airways pressure; Fio2, fractional inspired oxygen; PIE, pulmonary interstitial emphysema. | ||
| Gestational age (weeks) | 26.4 (24.9–28.3) | 29.1 (27.8–30.6)** |
| Birth weight (g) | 860 (706–1148) | 1168 (1034–1329)** |
| Sex (M/F) | 27 (60%):18 (40%) | 45 (49%):47 (51%) |
| Mode of delivery (caesarean section: instrumental:normal) | 17 (38%):0 (0%):28 (62%) | 61 (66%):1 (1%):30 (33%)** |
| Birth order (singleton:twins:triplets) | 40 (89%):4 (9%):1 (2%) | 70 (76%):20 (22%):2 (2%) |
| Inborn:outborn | 44 (98%):1 (2%) | 89 (97%):3 (3%) |
| Prolonged rupture membrane >24 hours | 10 (22%) | 18 (20%) |
| Pre-eclampsia | 3 (7%) | 15 (16%) |
| Antepartum haemorrhage | 7 (16%) | 15 (16%) |
| Apgar scores | ||
| 1 min | 5 (4–7) | 7 (5–8)** |
| 5 min | 8 (7–9) | 9 (8–9)* |
| Antenatal dexamethasone | ||
| Cumulative doses (mg) | 20 (0–40) | 20 (20–38) |
| Time between last dose and delivery (h) | 30 (5–50) | 13 (4–52) |
| Respiratory indices and outcomes | ||
| CRIB score | 5 (2–10) | 2 (1–4)** |
| OI (first 12 hours) | 7.7 (4.1–12.3) | 4.7 (2.0–10.0)* |
| A-aDo2 gradient (first 12 hours) | 250 (125–373) | 123 (47–261)** |
| Mechanical ventilation (day 7):no ventilation and CPAP v IPPV and HFOV | 16 (36%):29 (64%) | 63 (68%):29 (32%)** |
| Duration of mechanical ventilation (days) | 34 (20–70) | 16 (7–34)** |
| Duration of oxygen supplementation (days) | 43 (28–87) | 9 (3–18)** |
| PIPmax (first 14 days) | 23 (20–25) | 20 (18–24)** |
| Pawmax (first 14 days) | 12 (10–15) | 10 (8–13)** |
| Fio2max (first 14 days) | 0.90 (0.79–1.00) | 0.50 (0.36–0.64)** |
| Postnatal corticosteroids | 31 (69%) | 12 (13%)** |
| Pneumothorax | 7 (16%) | 0 (0%)** |
| PIE | 12 (27%) | 2 (2%)** |
| Pulmonary haemorrhage | 1 (2%) | 2 (2%) |
| Duration of hospital stay (days) | 124 (74–155) | 85 (66–103)** |
| Died | 18 (40%) | 0 (0%)** |