Table 4

Guidelines for platelet transfusion in the newborn

Platelet count (× 109/l)Non-bleeding neonateBleeding neonateNAITP (proven or suspected)
NAITP, Neonatal alloimmune thrombocytopenia; HPA, human platelet antigen; IVH, intraventricular haemorrhage; ET, endotracheal.
<30Consider transfusion in all patientsTransfuseTransfuse (with HPA compatible platelets)
30–49Do not transfuse if clinically stableTransfuseTransfuse (with HPA compatible platelets if any bleeding)
Consider transfusion if:

  • <1000 g and <1 week of age

  • clinically unstable (e.g. fluctuating blood pressure or perfusion)

  • previous major bleeding (e.g. grade 3–4 IVH or pulmonary haemorrhage)

  • current minor bleeding (e.g. petechiae, puncture site oozing or blood stained ET secretions)

  • concurrent coagulopathy

  • requires surgery or exchange transfusion

50–99Do not transfuseTransfuseTransfuse (with HPA compatible platelets if major bleeding present)
>99Do not transfuseDo not transfuseDo not transfuse