Table 2

 Basic details of the control, no treatment, and treatment groups of newborns

Control (n = 10)No treatment (n = 13)Treatment (n = 27)
Where applicable, values are mean (SD; range).
*Significantly different from the control group (p<0.001).
†Signficantly different from the control group (p<0.01).
‡Significantly different from the treatment group (p = 0.01).
Male:female5:56:717:10
Gestational age (weeks)39 (1; 37–41)37 (1; 35–39)*‡39 (2; 35–41)
Birth weight (g)3513 (346; 3000–4020)2690 (381; 2030–3255)*2985 (531; 2030–3880)†
Centile59 (23; 16–92)19 (19; 1–61)*30 (25; 1–76)†
Postnatal age at study (days)3 (1; 2–6)3 (1; 2–5)3 (2; 1–10)
Maternal history of drug useNoYesYes
Stable on methadone46%48%
Using methadone and heroin15%11%
Heroin only23%8%
Using methadone, heroin and other drugs16%33%
Mean methadone dose (mg)55 (29; 10–100 )79 (35; 13–180 )