Clinical details of included studies
| Study (year) | n | Participants | Dose* | Long term follow up |
|---|---|---|---|---|
| *Doses were either 0.1 or 0.2 mg/kg and dosing interval 12 or 24 hours. | ||||
| BW, Birth weight; GA, gestational age; MDI, mental developmental index; PDI, physical developmental index; CP, cerebral palsy. | ||||
| Bada (1989) | 141 | BW <1500 g | 3 doses starting at 6 hours | No |
| Bandstra (1988) | 199 | BW <1300 g | 3 doses starting at <12 hours | Between 6 and 24 months: Bayley MDI and PDI |
| Couser (1996) | 93 | BW 600–1250 g | 6 doses starting <24 hours | No |
| Domenico (1994) | 100 | BW <1250 g | 3 doses starting <12 hours | No |
| Gutierrez (1987) | 59 | GA <34 weeks and BW <1751 g | 3 doses starting <24 hours | No |
| Hanigan (1988) | 111 | BW <1500 g | 3 doses starting <12 hours | No |
| Krueger (1987) | 32 | BW 750–1500 g | Single dose at 24 hours | No |
| Mahony (1985) | 110 | BW 700–1300 g | 3 doses starting at 12–18 hours | No |
| Ment (1985) | 48 | BW 600–1250 g | 5 doses starting at 6 hours | No |
| Ment (1988) | 36 | BW 600–1250g | 3 doses starting at 6–12 hours | No |
| Ment (1994a) | 61 | BW 600–1250 g | 3 doses starting at 6–12 hours | No |
| Ment (1994b) | 431 | BW 600–1250 g | 3 doses starting at 6–12 hours | At 36 and 54 months: Stanford Binet Intelligence Scale Peabody Picture Vocabulary Test (R), CP, blindness, deafness |
| Morales-Suarez (1994) | 80 | GA 28–36 weeks | 3 doses starting <12 hours | No |
| Puckett (1985) | 32 | BW <1400 g | 3 doses starting at <24 hours | No |
| Rennie (1986) | 50 | BW <1750 g | 3 doses starting <24 hours | No |
| Supapannachart (1999) | 30 | BW <1250 g | 3 doses starting <24 hours | No |
| Schmidt (2001) | 1202 | BW 500–999 g | 3 doses starting <6 hours | At 18 months: Bayley MDI, blindness, deafness, CP |
| Vincer (1987) | 30 | BW <1500 g | 3 doses starting at 12 hours | At 24 months: CP |
| Yaseen (1997) | 27 | BW <1750 1g | 3 doses starting at 12 hours | No |