Characteristics of studies included
| Gestation | Birth weight (g) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Study | Methods | Participants | IVIG | C | IVIG | C | No of infants in study | IVIG dose | Exchange transfusion criteria | Outcomes reported | Jadad score |
| Gestation and birth weight are given as means (SD). | |||||||||||
| *Information given in Rübo and Wahn.18 | |||||||||||
| IVIG, Intravenous immunoglobulin group; C, control group; Rh, rhesus; HDN, haemolytic disease of the newborn; DCT, direct Coomb’s test; Retics, reticulocyte count; SBR, serum bilirubin; nk, not known. | |||||||||||
| Alpay et al15 | Single centre | ABO and/or RH HDN, DCT +ve, Retics ≥10% | nk | nk | 3413 (116.4) | 3396 (63.9) | 116 | 1 g/kg over 4 hours | SBR >290 μmol/l and increasing by >17 μmol/l/hour | Exchange transfusion, phototherapy duration, length of hospital stay, late anaemia | 2 |
| Dagoglu et al16 | Single centre, random number, sealed envelopes | Rh HDN, DCT +ve, Rh −ve Mum | 36.1 (2.3) | 36.1 (1.7) | 2851 (469) | 2690 (346) | 41 | 0.5 g/kg | SBR >340 μmol/l in the first 72 hours or increasing by >17 μmol/l/hour | Exchange transfusion, late anaemia | 3 |
| Rübo et al17 | Multicentre | Rh HDN, DCT +ve, Rh −ve Mum | nk | nk | 3119* (546) | 2899* (562) | 32 | 0.5 g/kg over 2 hours | SBR >34 μmol/l above Polácek’s exchange lines | Exchange transfusion, late anaemia | 1 |
| Voto et al19 | Single centre | Rh HDN, DCT +ve, RH +ve infant | 37 (3) | 37.5 (2.5) | 2803 (573) | 2866 (579) | 37 | 0.8 g/kg/day given daily for 3 days | Based on postnatal age, birth weight and SBR, as defined in their paper | Exchange transfusion, phototherapy duration, length of hospital stay | 1 |