Table 1

Bone mineral content (BMC) of the radial shaft, forearm shaft, and distal forearm in prematurely born children with different vitamin D receptor (VDR), oestrogen receptor (ERα) and collagen type I α1 (COLIA1) genotypes

At 3 monthsAt 9 to 11 years
Radial shaft BMC (g/cm)Forearm shaft BMC (g)Distal forearm BMC (g)Lumbar BMC (g)
nMean (SD)p ValuenMean (SD)p ValueMean (SD)p ValueMean (SD)p Value
VDR
ApaI
  aa40.09 (0.03)80.80 (0.19)0.86 (0.20)19.53 (5.57)
  Aa70.11 (0.04)0.46190.80 (0.17)0.880.90 (0.25)0.8719.60 (4.58)0.39
  AA50.09 (0.02)120.79 (0.21)0.91 (0.30)20.95 (4.93)
FokI
  ff20.09 (0.05)50.86 (0.23)0.93 (0.32)22.19 (6.99)
  Ff100.10 (0.04)210.72 (0.17)0.120.82 (0.25)<0.0118.49 (4.63)0.74
  FF40.08 (0.02)130.88 (0.13)1.00 (0.21)21.60 (3.53)
TaqI
  tt20.11 (0.01)60.76 (0.26)0.94 (0.40)21.01 (6.39)
  Tt60.09 (0.04)0.02200.80 (0.16)0.530.91 (0.25)0.4320.44 (4.60)0.34
  TT80.09 (0.03)130.80 (0.19)0.85 (0.18)18.86 (4.51)
ERα
PvuII
  pp10.1280.81 (0.24)0.90 (0.36)21.29 (7.37)
  pP120.09 (0.04)230.81 (0.17)0.650.91 (0.25)0.3620.00 (4.20)0.87
  PP30.09 (0.01)80.72 (0.13)0.83 (0.14)18.74 (2.99)
COLIA1
 ss10.1610.980.9119.08
 Ss10.1060.86 (0.18)1.07 (0.36)21.70 (5.61)
 SS140.09310.78 (0.18)0.86 (0.23)19.63 (4.81)
  • p Values were obtained by analysis of covariance with genotypes aa, Aa, and AA, ff, Ff, and FF, tt, Tt, and TT, pp, pP, and PP, or ss, Ss, and SS as factors and weight at time of measurement of bone mineral status as covariate.

  • The p values for the VDR FokI, ERαPvuII and COLIA1 genotypes are not reported because the distributions are not representative.