pH, base excess (BE), cortisol levels, patent ductus arteriosus (PDA), and cardiovascular variables during the insult and at 24 hours in normothermic and hypothermic pigs exposed to severe or mild and moderate hypoxic-ischaemic (HI) insult
| Normothermic (39°C) (n=17) | Hypothermic (35°C) (n=18) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Total (n=17) | Severe HI insult (n=7) | Mild & moderate HI (n=10) | p Value | Total (n=18) | Severe HI insult (n=6) | Mild & moderate HI insult (n=12) | p Value | ||
| Values are mean (SD). p Value is for severe v mild & moderate HI. | |||||||||
| MABP, Mean arterial blood pressure. | |||||||||
| Duration of low amplitude EEG (minutes) | During HI | 27.5 (6.9) | 34.1 (3.7) | 22.7 (3.5) | 0.003 | 25.1 (10.0) | 37.3 (3.5) | 18.5 (3.1) | <0.001 |
| Average MABP (mm Hg) | During HI | 48 (10) | 46 (7) | 50 (11) | ns | 46 (8) | 43 (3) | 47 (9) | ns |
| pH | End of HI | 6.97 (0.13) | 7.00 (0.11) | 6.95 (0.11) | ns | 6.99 (0.11) | 6.98 (0.12) | 7.00 (0.12) | ns |
| BE (mmol/l) | End of HI | −24.8 (4.6) | −23.2 (4.0) | −25.9 (4.8) | ns | −24.0 (4.1) | −23.4 (4.9) | −25.9 (4.8) | ns |
| HR (beats/min) | At 24 h | 186 (35) | 178 (28) | 193 (40) | ns | 166 (35) | 137 (37) | 180 (25) | 0.016 |
| MABP (mm Hg) | At 24 h | 66 (14) | 66 (14) | 67 (14) | ns | 67 (12) | 70 (7) | 67 (14) | ns |
| PDA | At 24 h | n=4 | n=1 | n=3 | ns | n=2 | n=1 | n=1 | ns |
| Cortisol (nmol/l) | At 24 h | 244 (144) | 284 (173) | 213 (118) | ns | 718 (285) | 729 (261) | 811 (290) | ns |