Summary of four cases of transplacental neonatal paracetamol poisoning that all occurred within 24 hours of maternal overdose, and this case of oral neonatal paracetamol poisoning
| Lederman2 | Roberts3 | Aw6 | Kumar8 | This case | ||||||
| Gestation (weeks) | 29 | 36 | Term | 38 | — | |||||
| Delivery time after overdose (hours) | 16 | 6 | 3 | 17 | — | |||||
| Maternal dose (g) | 32.5 | 20 | 20 | 26 | — | |||||
| Maternal hepatotoxicity | Yes | No | No | No | — | |||||
| AST 4300 U/l | ||||||||||
| Neonatal Tβ | 26 | 10 | 7.51-150 | 5.51-150 | 5.7 | |||||
| Peak AST (U/l) | 86 | NR | 86 | Normal | 18 (ALT) | |||||
| Prothrombin time | 28 | NR | 44 | NR | 13.9 | |||||
| Treatment | ExTx | ExTx (maternal methionine) | NAC | Supportive (maternal NAC) | NAC, charcoal | |||||
| Outcome | NAD | NAD | NAD | NAD | NAD | |||||
↵1-150 Estimated from paracetamol levels supplied in the original case reports.
Tβ, Plasma half life; AST, aspartate transaminase; ALT, alanine transaminase; NR, not reported; NAC, N-acetylcysteine; ExTx, exchange transfusion; NAD, no abnormality discovered.