Table 1

Summary of infants with punctate lesions

							MRI and characterisation of punctate lesions
										Distribution
			Perinatal							Ant region		Mid region		Post region			Follow up
Patients	Sex	Antenatal	GA (weeks)	Weight (g)	Delivery	Neonatal events	Age (days)	Number	Appearance	U	B	U	B	U	B	Associated lesions	Age at last exam (months)	Neurological outcome
(A) Preterm infants with isolated punctate lesions; (B) preterm infants with punctate lesions and associated major brain damage; (C) term infants with punctate lesions. F, female; M, male; N, normal; IUGR, intrauterine growth retardation; GA, gestational age; SVD, spontaneous vaginal delivery; EmCS, emergency caesarean section; ElCS, elective caesarean section; NA, not available; CUS, cranial ultrasound; IVH, intraventricular haemorrhage; MRI, magnetic resonance imaging; U, unilateral; B, bilateral; PVL, periventricular leucomalacia.
A
1	M	Hypothyroidium	28	1220	SVD	Ventilated 3 days	7	>10	Mixed				+		+	–	14	N

3
2	M	Premature rupture of membranes	32	2130	SVD	Ventilated 2 days	3	>10	Linear				+		+	Oedema	23	N

3	F	N	28	1110	ElCS	Ventilated 2 days Colonic perforation	82	>10	Linear				+			Oedema	18	N

4	F	N	30	1700	SVD	Ventilated 3 hours CUS day 2: IVH grade IIb	9	3–10	Linear				+			Oedema	25	Discrete delay in language

5	M	Polyhydramnion	36	2540	SVD	Collapse due to atrial tachycardia Hypothyroidism	13	3–10	Cluster			+				–	20	N

6	M	Pre-eclampsia IUGR	27	580	EmCS	CUS day 2: IVH grade IIb Hypotension	44	<3	Cluster					+		Oedema	23	N

7	F	Hypertension	31	1360	EmCS	Ventilated 2 days	7	<3	Cluster			+				–	22	N

8	F	Hypertension IUGR	34	1260	ElCS	Resuscitation at birth	2	<3	Cluster			+				–	18	N


B
9	M	N	35	1875	SVD	Perforated necrotising enterocolitis	27	>10	Cluster			+		+		Cerebellar hemorrhage	16	N

10	M	N	30	1320	SVD	Ventilated 1 day CUS day 7: bilateral PVL	13	>10	Linear		+		+		+	Cystic PVL	–	Died

						CUS day 7: bilateral PVL
11	F	N	29	1150	EmCS	CUS day 2: IVH grade IIb	26	>10	Linear				+		+	Cystic PVL	15	Cerebral palsy

12	M	Gestational diabetes	36	3960	EmCS	Resuscitation at birth	12	>10	Mixed		+		+		+	Basal ganglia emorrhage	19	N

13	M	Discordant twins	30	1200	EmCS	CUS week 2: bilateral PVL	29	>10	Linear				+		+	Cystic PVL	20	Cerebral palsy

14	M	IUGR	33	1200	EmCS	CUS day 1: IVH grade IIb	18	3–10	Mixed		+		+			Cystic PVL	16	Cerebral palsy
						Left renal vein thrombosis	25	–	–

15	M	N	33	3430	SVD	Fits day 13 due to herpetic encephalitis	19	3–10	Cluster			+				Herpetic encephalitis	26	Cerebral palsy Epilepsy

C
16	F	N	40	3025	SVD	Incontinentia pigmenti Fits day 5, EEG normal	51	>10	Cluster		+					–	24	N

17	F	N	40	3055	SVD	CUS day 1: subarachnoid	6	<3	Cluster					+		Subarachnoid	15	N
						haemorrhage	34	–	–							haemorrhage