Clinical data
| Patient No |
Gestational age (weeks) Birth weight (g) | Underlying disease | Thrombus (locus and day of life) Central line | rt-PA bolus (mg/kg)/ therapy (mg/kg/day)/ duration (days) | Heparin dose (IU/kg/day) Prophylaxis (dose/duration) | Clot outcome Complications | ||||
| 1 | 32 | IDM | In right atrium at day 9 | 0.7/ 0.2/ 4 | 100 | + | ||||
| 2200 | neonatal sepsis | UVC | 100/ 10 | None | ||||||
| 2 | 40 | IDM | In right atrium at day 8 | 0.7/ 0.2 → 0.1/ 2 | 150 | + | ||||
| 5360 | hypoglycaemia | UVC | 100– 50/ 5 | None | ||||||
| 3 | 35 | IDM, RDS | In right atrium at day 21 | 0.7/ 0.2/ 1 | 250 | + | ||||
| 1980 | UVC | 100/ 5 | None | |||||||
| 4 | 37 | IDM | In right atrium at day 10 | 0.7/ 0.2/ 2 | 150 | − | ||||
| 4300 | transient tachypnoea | UVC | None | Local bleeding | ||||||
| 5 | 35 | RDS, PPHN | In aorta at day 15 | 0.7/ 0.2/ 1 | 150 | + | ||||
| 3040 | neonatal sepsis | UVC and UAC | 100/ 2 | None | ||||||
| 6 | 40 | peripartal asphyxia | In aorta at day 22 | 0.7/ 0.2 → 0.3/ 3 | 150 | + | ||||
| 3450 | PPHN, neonatal sepsis | UVC and UAC | 100/ 7 | None | ||||||
| 7 | 30 | RDS, PDA | In left atrium at day 12 | 0.7/ 0.2/ 1 | 150 | + | ||||
| 1190 | neonatal sepsis | UVC and UAC | 100/ 5 | None | ||||||
| 8 | 33 | SGA, RDS | In right atrium at day 19 | 0.7/ 0.2 → 0.3/ 2 | 250 | (+) | ||||
| 1450 | neonatal sepsis | UVC | 100/ 1 | AT3-deficiency | ||||||
| 9 | 3 | IDM, RDS | In right atrium at day 6 | 0.7 (2 times)/ | 150 | + | ||||
| 1315 | neonatal sepsis | UVC | 0.2 → 0.3 → 0.2/ 5 | 100/ 7 | None | |||||
| 10 | 42 | Peripartal asphyxia | In right atrium at day 16 | 0.7/ 0.2/ 4 | 100 | + | ||||
| 4550 | IDM, MAS, PPHN | UVC | 100–50/ 5 | Local bleeding | ||||||
| neonatal sepsis | ||||||||||
| 11 | 40 | RDS, SGA | In right atrium at day 14 | 0.7/ 0.2/ 3 | 200 | + | ||||
| 1900 | neonatal sepsis | UVC | 150–100/ 4 | None | ||||||
| 12 | 24 | RDS, IVH | In right atrium (6th month) | 0.7/ 0.2/ 4 (2 times) | 100 | + | ||||
| 585 | neonatal sepsis | CVL and VAS | 150–50/ 6 | None | ||||||
| 13 | 41 | Peripartal asphyxia | In right atrium at day 21 | 0.7/ 0.2/ 4 | 150 | (+) | ||||
| 4200 | MAS, PPHN | UVC | 150–100/ 4 | None | ||||||
| 14 | 27 | RDS, SGA | In aorta at day 3 | 0.7 (3 times)/ | 200 (interrupted) | + | ||||
| 750 | neonatal sepsis | UVC and UAC | 0.2/ 3 (interrupted) | 100–50/ 2 | None | |||||
rt-PA, Recombinant tissue plasminogen activator; IDM, infants of diabetic mothers; RDS, respiratory distress syndrome; PPHN, persistent pulmonary hypertension; PDA, patent ductus arteriosus; SGS, small for gestational age; MAS, meconium aspiration; IVH, intraventricular haemorrhage; UVC, umbilical venous catheter; UAC, umbilical artery catheter, CVL, central venous line; VAS, ventricular-atrial shunt.