Table 1

Selected values (taken from Weiner et al18) for components of the coagulation, coagulation inhibitor, and fibrinolytic system in neonates

Coagulation testsReference valuesPreferred values under treatment with rt-PA
Preterm infantsFull term infants
PT (seconds)14.6–16.911.8–13.0∼30–40
PT (%)31–4848–68⩾40
aPTT (seconds)80–16840.4–42.9∼50–60
Fibrinogen (mg/dl)160–550270–312⩾150
ATIII (U/ml)0.38–0.590.62–0.78
ATIII (%)28–3863–78⩾50
Plasminogen (U/ml)1.70–1.911.95–2.17
  • The reference values for the preterm infants are values at birth, and those for the full term infants are mean values during the first month of life. rt-PA treatment was monitored only by PT (in seconds and %), aPTT, ATIII (%), fibrinogen, and fibrin split products.

  • PT, Prothrombin time; aPTT, activated partial thromboplastin time; ATIII, antithrombin III; rt-PA, recombinant tissue plasminogen activator.