Table 1

Neuroblastoma in the neonatal period; characteristics of 33 tumours 1986–94

Stage	Age at diagnosis (days)	Prenatal ultrasound	Presentation	Primary site	Other sites	Treatment	Outcome	Complications
1	1	Normal	Abdominal mass	Adrenal	Nil	S	Alive
1	2	? Neuroblastoma	Prenatal ultrasound	Adrenal	Nil	S	Alive
1	10	Normal	Neck mass	Cervical	Nil	S	Alive
2	0	Not documented	Tachycardia, sweaty, hypertensive	Abdominal	Nil	S	Alive	Infarcted left kidney post operatively
2	15	Not documented	Stridor	Cervical	Nil	S+C	Alive
2	16	Not documented	Abdominal mass	Adrenal	LN	S	Alive
2	16	Not documented	Lower limb neurology, incontinence	Intraspinal L1/L2	Nil	S	Alive	Neuropathic bladder, walking aids
2	18	Not documented	Abdominal mass	Adrenal	Nil	S	Alive
3	0	Not documented	Birth asphyxia	Thoracic	Paraspinal extension	S	Alive	Abnormal sweating
3	6	Normal	Abdominal mass	Adrenal	LN	S+C	Alive
3	11	Not documented	Abdominal distension	Thoracic	Intraspinal extension	S+C	Alive	Kyphoscoliosis
3	18	Reduced movement of lower limbs	Lower limb neurology	Adrenal	Intraspinal extension	S+C	Alive	Flaccid paralysis lower limbs
3	22	Not documented	Lower limb neurology	Thoraco- abdominal	LN, paraspinal extension	S+C	Alive	Scoliosis
3	26	Not documented	Respiratory distress	Thoracic	Intraspinal extension	S+C	Alive	Flaccid paralysis lower limbs
3	27	Not documented	Urinary dribbling	Adrenal	Intraspinal extension	S+C	Alive	Incontinent, walking aids
4	0	Normal	Hydrops	Adrenal	Liver, brain, heart, bone, muscle, lungs	Nil	Stillbirth
4	1	? Neuroblastoma	Abdominal distension, hydrops	Adrenal (bilateral)	Liver	C	Died
4	1	? Neuroblastoma	Prenatal ultrasound	Adrenal	Liver, BM, pleura	S+C	Alive
4	27	Normal	Abdominal distension	Adrenal	Liver, BM, LN	S+C+BMT	Alive	High tone deafness
4S	0	? Neuroblastoma	Prenatal ultrasound	Adrenal	Liver	S	Alive
4S	0	? Neuroblastoma	Prenatal ultrasound	Adrenal	Liver	C	Alive	Learning difficulties
4S	1	Not documented	Skin nodules	Unknown	Skin	Nil	Died
4S	2	Not documented	Intestinal obstruction	Adrenal	Liver	S	Alive
4S	2	Not documented	Abdominal mass	Adrenal	Liver, LN	C	Alive
4S	5	Not documented	Abdominal distension	Adrenal	Liver	S+C+R	Alive
4S	8	Not documented	Abdominal mass	Adrenal	Liver	Nil	Alive
4S	9	Not documented	Abdominal mass	Liver	Liver	R	Alive
4S	13	Not documented	Abdominal mass	Adrenal	Liver, BM	Nil	Alive
4S	14	Cyst right kidney	Abdominal mass	Adrenal	Liver, BM	C	Alive
4S	19	Not documented	Skin nodules	Adrenal	Liver, BM, skin	Nil	Alive
4S	21	Not documented	Skin nodules	Adrenal	Liver, skin	Nil	Alive
4S	26	Not documented	Abdominal distension	Adrenal	Liver, BM	C	Alive
4S	26	Not documented	Abdominal mass	Adrenal	Liver	S	Alive

S = surgery; C = chemotherapy; R = radiotherapy; BMT = bone marrow transplant; LN = lymph nodes; BM = bone marrow.