Table 4

Pharmacokinetic parameter estimates from basic and final models

Basic model Final model
Clearance (l/h)0.08443.56 × weight /
creatinine concentration
Interpatient variability on clearance67%22%
Volume (l)1.010.669 × weight
Interpatient variability on volume58%18%
Residual error on concentration (mg/l)4.804.53
  • NB variability in clearance and volume of distribution between individuals is expressed as a percentage coefficient of variation.

  • %SE = standard error of parameter estimate expressed as a percentage.