Table 1

Estimates of vancomycin pharmacokinetic parameters from previous studies in neonates and young infants

Reference No PCA (weeks) PNA (days) CL (l/h/kg) Volume (l/kg) Factors affecting CL Factors affecting V Data analysis
8 4427–442–63 1-1500.06–0.080.56Weight, PCAWeightMultiple linear regression
9 1627–367–430.073 l/h0.53Weight, BSA, PCAWeight, BSA, PCALinear regression
10 1129–487–700.032–0.48 l/h0.44–2.5 (l)PCA, weight, creatinineWeightMultiple linear regression
11 1734–618–1980.055–0.210.33–0.81PCANoneLinear regression
12 2326–466–1020.019–0.190.41–0.73PCA, weight, GA, PNAWeight, PCA, BSALinear regression
13 2025–41NSNS0.69PCA, weight, creatinineNoneNon-linear regression
14 1330–5613–1830.018–0.210.25–0.81PCA, weight, PNANoneLinear regression
17 1326–364–170.022–0.0670.46–0.55CreatinineLinear regression
18 192NS1–730.063 (x 0.455 dop)0.50Weight, GA, dopamineWeightPopulation (NONMEM)
(x 0.656 GA<32)
19 21NSNS0.9–1.8 (l/h/1.73m2)0.69–0.74NSNS
  • 1-150 Mean results from three patient groups.

  • PCA = postconceptual age; PNA = postnatal age; CL = clearance; V = volume of distribution; BSA = body surface area; NS = not stated; dop = concurrent use of dopamine; GA<32 = gestational age <32 weeks.