Reference | No | PCA (weeks) | PNA (days) | CL (l/h/kg) | Volume (l/kg) | Factors affecting CL | Factors affecting V | Data analysis | ||||||||
8 | 44 | 27–44 | 2–63 | 1-1500.06–0.08 | 0.56 | Weight, PCA | Weight | Multiple linear regression | ||||||||
9 | 16 | 27–36 | 7–43 | 0.073 l/h | 0.53 | Weight, BSA, PCA | Weight, BSA, PCA | Linear regression | ||||||||
10 | 11 | 29–48 | 7–70 | 0.032–0.48 l/h | 0.44–2.5 (l) | PCA, weight, creatinine | Weight | Multiple linear regression | ||||||||
11 | 17 | 34–61 | 8–198 | 0.055–0.21 | 0.33–0.81 | PCA | None | Linear regression | ||||||||
12 | 23 | 26–46 | 6–102 | 0.019–0.19 | 0.41–0.73 | PCA, weight, GA, PNA | Weight, PCA, BSA | Linear regression | ||||||||
13 | 20 | 25–41 | NS | NS | 0.69 | PCA, weight, creatinine | None | Non-linear regression | ||||||||
14 | 13 | 30–56 | 13–183 | 0.018–0.21 | 0.25–0.81 | PCA, weight, PNA | None | Linear regression | ||||||||
17 | 13 | 26–36 | 4–17 | 0.022–0.067 | 0.46–0.55 | Creatinine | Linear regression | |||||||||
18 | 192 | NS | 1–73 | 0.063 (x 0.455 dop) | 0.50 | Weight, GA, dopamine | Weight | Population (NONMEM) | ||||||||
(x 0.656 GA<32) | ||||||||||||||||
19 | 21 | NS | NS | 0.9–1.8 (l/h/1.73m2) | 0.69–0.74 | NS | NS |
↵1-150 Mean results from three patient groups.
PCA = postconceptual age; PNA = postnatal age; CL = clearance; V = volume of distribution; BSA = body surface area; NS = not stated; dop = concurrent use of dopamine; GA<32 = gestational age <32 weeks.