Hospital organisation, clinical characteristics, and unadjusted outcomes for 2612 very low birthweight (VLBW) or preterm infants admitted to Scottish and Australian neonatal intensive care units in 1993 and 1994
Scottish tertiary centres | Scottish non-tertiary centres | Australian tertiary centres | p Value | |
Number of centres | 5 | 3 | 6 | |
Total VLBW/preterm infants admitted | 827 | 156 | 1629 | 0.00011-151 |
Number of intensive care cots1-150 | 10 (10, 20) | 4 (4, 6) | 20 (13, 20) | 0.00011-151 |
Annual volume of VLBW/preterm infants per centre1-150 | 104 (65, 121) | 30 (30, 31) | 297 (255, 422) | 0.00011-151 |
Gestation (weeks)1-150 | 29 (27, 31) | 29 (27, 31) | 29 (27, 30) | 0.0161-151 |
Birth weight (g)1-150 | 1180 (900, 1400) | 1171 (880, 1388) | 1166 (908, 1375) | 0.6651-151 |
Five minute Apgar score1-150 | 9 (7, 9) | 9 (7, 9) | 8 (7, 9) | 0.00011-151 |
Worst base excess in first 12 hours (mmol/l)1-150 | −5 (−8.45, −2) | −5 (−8.85, −2.6) | −4.05 (−6.7, −1.9) | 0.00011-151 |
Maximum Fio 2in first 12 hours1-150 | 0.5 (0.25, 0.77) | 0.5 (0.3, 0.8) | 0.45 (0.26, 0.75) | 0.4491-151 |
Minimum Fio 2 in first 12 hours1-150 | 0.21 (0.21, 0.38) | 0.25 (0.21, 0.4) | 0.25 (0.21, 0.4) | 0.00031-151 |
CRIB score1-150 | 2 (1,6) (n = 761) | 3 (1,7) (n = 136) | 2 (1,6) (n = 1476) | 0.4101-151 |
Hospital deaths (%) | 172/775 (22%)1-152 | 33/148 (22%)1-152 | 216/1628 (13%) | < 0.00011-154 |
Major brain damage in infants who had ultrasound scanning (%) | 87/734 (12%) | 12/151 (8%) | 118/1480 (8%) | < 0.00011-154 |
↵1-150 Median (interquartile range).
↵1-151 From Kruskal-Wallis test for three independent samples.
↵1-152 If all missing cases in Scotland had survived, the hospital mortality for Scottish neonatal intensive care units would be 20.9%. If the missing case in Australia had died, the hospital mortality rate would be 13.3%. The difference between these rates remains statistically significant.
↵1-154 From χ2 test for 2 × 2 table comparing Scottish and Australian infants.