Outcomes of 17 T and Tk antigen activated infants compared with outcomes of 28 weight and gestation matched controls who developed NEC after September 1991
| Variable | T/Tk antigen activated infants (%) | Matched control infants (%) | Odds ratios (95% confidence intervals) | p Value |
|---|---|---|---|---|
| Number of infants | 17 | 28 | ||
| Died | 6 (35%) | 2 (7%) | 7.1 (1.2, 40.8) | 0.04* |
| Surgery for NEC | 11 (65%) | 14 (50%) | 1.8 (0.5, 6.3) | 0.37 NS |
| Haemolysis on blood film | 12 (71%) | 6 (21%) | 8.8 (2.2, 35.0) | 0.002* |
| Bilirubin ⩾250 μmol/l with NEC | 3 (18%) | 1 (4%) | 5.8 (0.5, 60.9) | 0.14 NS |
| Exchange transfusion | 1 (6%) | 0 (0%) | 5.2 (0.2, 134.8) | 0.38 NS |
| Hyperkalaemia (K+⩾6.5 mmol/l) | 8 (47%) | 1 (4%) | 24 (2.6, 219.2) | 0.0008* |
| Haematuria (UA ⩾ 3+) | 7 (41%) | 1 (4%) | 18.9 (2.1, 173.7) | 0.003* |
| Anuria | 6 (35%) | 1 (4%) | 14.7 (1.6, 137.1) | 0.008* |
| Maximum creatinine (SD) (μmol/l) | 104.6 (42.6) | 74.4 (29.2) | 0.02* | |
| Hypotension treated with inotropes | 12 (71%) | 11 (39%) | 3.7 (1.0, 13.5) | 0.07 NS |
| Acidosis treated with bicarbonate | 6 (35%) | 2 (7%) | 7.1 (1.2, 40.8) | 0.04* |
| Colloid required (SD) (ml/kg) | 69 (35) | 31 (23) | 0.0005* | |
| Blood transfusions (SD) (ml/kg) | 48 (33) | 42 (28) | 0.52 NS | |
| Mean lowest platelet count (×109/l) (SD) | 152 (139) | 228 (177) | 0.14 NS | |
| Platelet transfusion given | 7 (41%) | 5 (18%) | 3.2 (0.8, 12.6) | 0.16 NS |
| Leucopenia (white cells <5.0 × 109/l) | 9 (53%) | 9 (32%) | 2.4 (0.7, 8.2) | 0.22 NS |
| Positive blood culture | 6 (35%) | 6 (21%) | 2.0 (0.5, 7.7) | 0.32 NS |
CI, confidence interval; * significant, p<0.05.