Effects of amiloride on responses to glucagon
| Concentration of glucagon (M) | Concentration of amiloride (M) | n | Rate of lung liquid production (m/h per kg body weight) | Reductions from the hour before treatment (ml/h per kg body weight) | Significance of reductions during treatment (p value) | Significance of reductions after treatment (P) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hour before treatment | Hour during treatment | Hour after treatment | Hour during treatment | Hour after treatment | ANOVA | Regression analysis | ANOVA | Regression analysis | |||||||||||
| 10−9 | 0 | 24 | 1.72 (0.14) | 0.05 (0.29) | 0.79 (0.14) | 1.67 (0.25) | 0.93 (0.24) | <0.001 | <0.0005 | >0.05 | <0.01 | ||||||||
| 10−9 | 10−6 | 12 | 2.15 (0.38) | 0.84 (0.57) | 1.88 (0.28) | 1.31 (0.39) | 0.27 (0.10) | <0.025 | <0.0025 | >0.05 | >0.05 | ||||||||
| 0 | 10−6 | 6 | 2.43 (0.37) | 1.41 (0.16) | 1.54 (0.51) | 1.02 (0.38) | 0.89 (0.33) | >0.05 | >0.05 | >0.05 | >0.05 | ||||||||
| 10−9 | 10−5 | 12 | 2.06 (0.28) | 1.45 (0.19) | 2.08 (0.46) | 0.61 (0.14) | −0.02 (0.01) | >0.05 | >0.05 | >0.05 | >0.05 | ||||||||
| 0 | 10−5 | 6 | 1.51 (0.60) | 1.38 (0.57) | 1.20 (0.54) | 0.13 (0.04) | 0.31 (0.12) | >0.05 | >0.05 | >0.05 | >0.05 | ||||||||
| Untreated controls | 12 | 1.59 (0.20) | 1.06 (0.17) | 0.96 (0.28) | 0.53 (0.17) | 0.63 (0.21) | >0.05 | >0.05 | >0.05 | >0.05 | |||||||||
All values are mean (SEM).