ECMO
| Trial No | Primary diagnosis | Therapy (circuit) | ECMO received | Oxygenation index at trial entry | Days ventilated (after randomisation) | Days in ⩾90% 02 (after treatment) | Cardiac pathology | Age at death (days) |
|---|---|---|---|---|---|---|---|---|
| 009 | Congenital diaphragmatic hernia | ECMO (VA) | Yes | 42 | 23 | 15 | Papillary muscle and subendocardial haemorrhage. Micro infarcts, foci of old and new injury. Necrosis of myocytes, polymorph infiltration (fig 1) and loose fibrous tissue. Fibrin attached endothelial surface RA | 35 |
| 041 | Congenital diaphragmatic hernia | ECMO | NR Died pre transport | Antemortem thrombus and fibrin attached endothelial surface RA (fig2) | 1 | |||
| 070 | Congenital diaphragmatic hernia | ECMO (VV) | Yes | 41 | 7+3+15 | 0 | Micro infarcts wall LV. Old injury. Necrotic myocytes and loose granulation tissue. | 127 |
| 093 | Pulmonary hypertension secondary to sepsis | ECMO | NR TAPVD | 58 | 11 | 2 | Mild fibrosis. Extensive calcification (old injury) (fig 3) | 201 |
| 098 (NO) | Pulmonary hypertension secondary to meconium aspiration Infradiaphragmatic TAPVD | ECMO (VV) | Yes | 121 | 0 | 0 | Micro infarct wall LV. Foci of old and new injury. Necrosis of myocytes with polymorph infiltration and foci of loose fibrous tissue. | 9 |
| 099 (NO) | Pulmonary hypoplasia | ECMO (VA) | Yes | 42 | 7 | 4 | Micro infarct wall RV. Foci of old and new injury. Necrosis of myocytes with polymorph infiltration and foci of early fibrosis. | 32 |
| 104 | Persistent fetal circulation | ECMO (VV) | Yes | 31 | 5+18 | 2+16 | Normal | 57 |
| 112 | Pulmonary hypertension secondary to IRDS. Pulmonary lymphangiectasia | ECMO (VV) | Yes | 55 | 0 | 0 | Normal | 33 |
| 136 | Persistent fetal circulation | ECMO | NR Consent withdrawn | 96 | 0 | 0 | Normal | 7 hours 15 mins |
| 149 | Pulmonary hypertension secondary to meconium aspiration | ECMO | NR IVH | 44 | 2 | 2 | Normal | 2 |
| 181 (NO) | Congenital diaphragmatic hernia | ECMO (VA) | Yes | 51 | 14 | 10 | Normal | 24 |
| 183 | Pulmonary hypertension secondary to sepsis | ECMO | NR Died pre transport | 176 | 0 | 0 | Normal | 1 |
NO = nitric oxide used as vasodilator; VA = venoarterial cannulation; RA /V = right atrium /ventricle; IVH = intraventricular haemorrhage; IRDS =idiopathic respiratory distress syndrome; NR = not received; VV = venovenous cannulation; LA /V = left atrium /ventricle; TAPVD = total anomalous pulmonary venous drainage