Table 3

The diagnostic criteria for hyperinsulinism

Glucose requirements > 6–8 mg/kg/min to maintain blood glucose above 2.6–3 mmol/litre
Laboratory blood glucose < 2.6 mmol/litre
Detectable insulin at the point of hypoglycaemia with raised C peptide
Inappropriately low blood free fatty acid and ketone body concentrations at the time of hypoglycaemia
Glycaemic response after the adminstration of glucagon when hypoglycaemic
Absence of ketonuria