Table 1

Virological, clinical, and neuroradiological data in 36 children with neonatal HSV infections

Case No		Neonatal disease		HSV-DNA		Aciclovir/no treatment	CT/MRI/HUS	Follow up neurodevelopmental outcome/years
Case No		Neonatal disease		CSF	S	Aciclovir/no treatment	CT/MRI/HUS	Follow up neurodevelopmental outcome/years
Maternal primary HSV-1 infection, no previous HSV infection with either type
1	DISS^*	ND	+(5)	None	ND	Normal+ keratitis/14y^*
2	CNS^*	ND	+(7)	None	ND	Normal/14y
3	CNS^*	ND	+(4)	Aciclovir	ND	Normal/1y
Maternal secondary HSV-1 infection (previous infection with HSV-1)
4	CNS^*	−	+(4)	Aciclovir	Normal	Normal/ 7y^*
5	DISS^*	ND	+(4)	None	ND	MMR/14y^*
External source HSV-1 infection (no maternal infection)
6	DISS	+	+(10)	Aciclovir	Normal	Normal/1y
7	CNS^*	+	+(1)	Aciclovir	Abnormal	Normal/1y
Maternal primary HSV-2 infection, no previousHSV infection with either type
8	CNS	ND	−(6)	None	ND	CP/18y^*
9	DISS	ND	+(2)	None	ND	Dead/1w
10	DISS	−	ND	None	ND	Dead/1w
11	CNS	+	+(1)	Aciclovir	Abnormal	Dead/4y
12	DISS,cong^*	−	ND	Aciclovir	Abnormal	CP+SMR/2y^*
Maternal primary HSV-2, previous HSV-1 infection
13	CNS	ND	−(5)	None	ND	CP+SMR/8y
14	CNS^*	ND	−(3)	None	Abnormal	CP+SMR/14y^*
15	CNS^*	−	−(6)	Aciclovir	ND	Normal/7y^*
16	CNS^*	−	−(4)	Aciclovir	Abnormal	CP+SMR/11y^*
17	CNS^*	+	ND	Aciclovir	Abnormal	CP+SMR/4y^*
18	CNS	+	−(2)	Aciclovir	Abnormal	CP/2y^*
Maternal secondary HSV-2 infection, (previous infection with HSV-2)
19	CNS^*	ND	−(9)	None	Abnormal	CP/18y^*
20	CNS	−	+(4)	Aciclovir	Abnormal	CP+MMR/14y^*
21	CNS^*	+	+(2)	Aciclovir	Abnormal	CP+SMR/12y^*
22	CNS	+	−(3)	Aciclovir	Abnormal	normal/10y^*
23	CNS^*	+	+(3)	Aciclovir	Abnormal	CP/6y^*
24	CNS^*	−	+(4)	Aciclovir	Abnormal	Normal+ keratitis/7y
25	CNS^*	+	+(6)	Aciclovir	Abnormal	Normal/1y^*
26	CNS	+	+(4)	Aciclovir	Abnormal	Normal /3.5y
27	CNS	+	+(5)	Aciclovir	Abnormal	CP+SMR/6y^*
28	CNS	+	+(7)	Aciclovir	Abnormal	Normal/1.5y
29	CNS	+	ND	Aciclovir	Abnormal	CP+/4y^*
30	CNS	+	+(6)	Aciclovir	Abnormal	CP+SMR/10y
31	CNS	+	−(3)	Aciclovir	Abnormal	CP+SMR/8y^*
32	CNS	+	−(20)	Aciclovir	Abnormal	CP+SMR/10y^*
33	CNS	+	+(3)	Aciclovir	Abnormal	CP+SMR/7y
34	CNS^*	+	+(1)	Aciclovir	Abnormal	dead/2.5y
35	SEM^*	+	ND	Aciclovir	Normal	Normal+ keratitis/3y
36	CNS	+	ND	Aciclovir	Abnormal	CP/1.5y

S = serum; CSF = cerebrospinal fluid;
1-151 figures in parentheses represent sampling day after onset of disease ND = no specimens/not done; CP = cerebral palsy; SMR/MMR = severe/mild mental retardation; Cong = congenital; Normal = No neurodevelopmental abnormality; CT/ MRI/HUS = computed tomography/ magnetic resonance imaging /head ultrasound; ^* = neonatal and/or subsequent recurrent vesicles.