Accuracy of C reactive protein assay as a diagnostic test for bacterial infection
| Author | Year | Reference | Positive test | Incidence of infection | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Positive LR (95% CI) | Negative LR (95% CI) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Adhikari | 1986 | 9 | “Positive” v “negative” | 19/43 | 84 | 71 | 70 | 85 | 2.89 (1.50 to 5.55) | 0.22 (0.08 to 0.65) | |||||||||||
| Seibert | 1990 | 52 | >10 mg/l (early infection) | Not given3-151 | 63 | 70 | 13 | 96 | 2.13-151 | 0.533-151 | |||||||||||
| Seibert | 1990 | 52 | >10 mg/l (late infection) | Not given3-151 | 57 | 61 | 30 | 82 | 1.53-151 | 0.703-151 | |||||||||||
| Krediet | 1992 | 35 | >7 mg/l (early infection) | 14/49 | 43 | 71 | 38 | 76 | 1.50 (0.67 to 3.34) | 0.80 (0.49 to 1.32) | |||||||||||
| Krediet | 1992 | 35 | >7 mg/l (late infection) | 25/48 | 84 | 48 | 64 | 73 | 1.61 (1.04 to 2.47) | 0.34 (0.12 to 0.90) | |||||||||||
| Peakman | 1992 | 39 | “Positive” v“negative” | 17/42 | 29 | 64 | 36 | 89 | 0.82 (0.33 to 2.02) | 1.11 (0.72 to 1.69) | |||||||||||
| Hiew | 1992 | 31 | >10 mg/l | 30/70 | 83 | 41 | 38 | 85 | 1.42 (1.10 to 1.83) | 0.40 (0.17 to 0.94) | |||||||||||
| Pourcyrous | 1993 | 42 | >9 mg/l (day 1) | 242/689 | 57 | 88 | 72 | 79 | 4.69 (3.57 to 6.16) | 0.49 (0.43 to 0.57) | |||||||||||
| Pourcyrous | 1993 | 42 | >9 mg/l (day 1, 2, or 3) | 242/689 | 77 | 76 | 63 | 85 | 3.17 (2.66 to 3.78) | 0.30 (0.24 to 0.38) | |||||||||||
| Edgar | 1994 | 21 | >6 mg/l | 43/60 | 35 | 100 | 100 | 38 | 12.56 (0.79 to 199.10) | 0.67 (0.53 to 0.85) | |||||||||||
| Philip | 1994 | 40 | >10 mg/l | 32/311 | 53 | 92 | 43 | 95 | 6.44 (3.87 to 10.72) | 0.51 (0.35 to 0.74) | |||||||||||
| Wagle | 1994 | 59 | >10 mg/l (day 1) | 51/309 | 63 | 87 | 49 | 92 | 4.91 (3.35 to 7.19) | 0.43 (0.30 to 0.61) | |||||||||||
| Wagle | 1994 | 59 | >10 mg/l (day 1 and/or day 2) | 51/309 | 90 | 81 | 48 | 98 | 4.65 (3.57 to 6.07) | 0.12 (0.53 to 0.28) | |||||||||||
↵3-151 The data presented in this report did not allow 2 × 2 tables to be created. It is not therefore possible to calculate the incidence of infection or confidence intervals around the likelihood ratios. CI = confidence interval; LR = likelihood ratio; NPV = negative predictive value; PPV = positive predictive value.