Table 5

Effect of dexamethasone on death

TrialsYearExpected observedExpected totalControls observedControls totalERR (95% CI)ERD (95% CI)NNT (95% CI)
When begun at <36 h of age:
Yeh et al 38 1994287520671.25  (0.70, 2.22)7.48  (−8.01, 22.97)
Shinwellet al 31 199631132221161.24 (0.72, 2.14)4.52 (−5.64, 14.68)
Rastogiet al 30 19964362341.89 (0.35, 10.31)5.23 (−7.73, 18.19)
Sander et al 32 19942197210.32 (0.07, 1.52)−22.81 (−47.24, 1.63)
Tapia et al 39 1996175518540.93 (0.48, 1.80)−2.42 (−19.95, 15.10)
Yeh et al 33 19903288290.39 (0.10, 1.46)−16.87 (−36.77, 3.02)
Pooled χ2=6.92 (df=5)83345773211.03 (0.78, 1.34)0.64 (−5.42, 6.69)
Subgroup when begun between 7–14 days of age:
Durandet al 34 19952234200.43 (0.08, 2.37)−11.30 (−32.28, 9.67)
Brozanskiet al 35 19952399390.22 (0.05, 1.03)−17.95 (−32.87, −3.02)
Cummingset al 37 19893126110.46 (0.11, 1.83)−29.55 (−67.84, 8.74)
Kari et al 36 19931173240.24 (0.01, 4.70)−6.62 (−23.94, 10.71)
Pooled [χ2=0.94 (df=3)]89121940.35 (0.16, 0.74)−12.13 (−20.97, −3.29)8  (4, 30)