Comparsion of the sensitivity, specificity, positive and negative predictive values of different combinations of biochemical tests using the calculated optimal cut off values and the manufacturers’ recommended values (in parentheses) during the first 48 hours of suspected clinical sepsis
| Combination of tests | Sensitivity | Specificity | PPV | NPV | |||||
|---|---|---|---|---|---|---|---|---|---|
| Day 0 | Day 1 | Day 2 | |||||||
| CRP/IL-6 | CRP | 0.98 (0.98) | 0.91 (0.68) | 0.90 (0.71) | 0.98 (0.97) | ||||
| CRP/IL-6 | TNFα | 0.98 (0.98) | 0.91 (0.63) | 0.90 (0.68) | 0.98 (0.97) | ||||
| IL-6/ TNFα | TNFα | 0.98 (0.98) | 0.80 (0.61) | 0.80 (0.67) | 0.98 (0.97) | ||||
| IL-6/ TNFα | CRP | 0.98 (0.98) | 0.79 (0.59) | 0.79 (0.66) | 0.98 (0.97) | ||||
| CRP/ TNFα | CRP/ TNFα | 0.98 (0.98) | 0.80 (0.75) | 0.80 (0.76) | 0.98 (0.98) | ||||
| IL-6/ TNFα | IL-6/TNFα | 0.98 (0.98) | 0.73 (0.50) | 0.75 (0.61) | 0.98 (0.97) | ||||
| CRP/IL-6/ TNFα | CRP/IL-6/ TNFα | 0.98 (0.98) | 0.73 (0.50) | 0.75 (0.61) | 0.98 (0.97) | ||||
| CRP/IL-6 | CRP/IL-6 | 0.98 (1.00) | 0.77 (0.50) | 0.77 (0.62) | 0.98 (1.00) | ||||
| CRP/IL-6/ TNFα | CRP/IL-6/ TNFα | 0.98 (1.00) | 0.66 (0.43) | 0.70 (0.58) | 0.97 (1.00) | ||||
| CRP/IL-6 | CRP/IL-6 | CRP/IL-6 | 0.98 (1.00) | 0.71 (0.47) | 0.73 (0.59) | 0.98 (1.00) | |||
| CRP/ TNFα | CRP/ TNFα | CRP/ TNFα | 0.98 (0.98) | 0.75 (0.70) | 0.76 (0.72) | 0.88 (0.98) | |||
| IL-6/ TNFα | IL-6/ TNFα | IL-6/ TNFα | 0.98 (1.00) | 0.63 (0.39) | 0.68 (0.57) | 0.97 (1.00) | |||
| CRP/IL-6/ TNFα | CRP/IL-6/ TNFα | CRP/IL-6/ TNFα | 0.98 (1.00) | 0.63 (0.39) | 0.68 (0.57) | 0.97 (1.00) | |||
PPV = positive predictive value; NPV = negative predictive value.