Combination of tests | Sensitivity | Specificity | PPV | NPV | |||||
---|---|---|---|---|---|---|---|---|---|
Day 0 | Day 1 | Day 2 | |||||||
CRP/IL-6 | CRP | 0.98 (0.98) | 0.91 (0.68) | 0.90 (0.71) | 0.98 (0.97) | ||||
CRP/IL-6 | TNFα | 0.98 (0.98) | 0.91 (0.63) | 0.90 (0.68) | 0.98 (0.97) | ||||
IL-6/ TNFα | TNFα | 0.98 (0.98) | 0.80 (0.61) | 0.80 (0.67) | 0.98 (0.97) | ||||
IL-6/ TNFα | CRP | 0.98 (0.98) | 0.79 (0.59) | 0.79 (0.66) | 0.98 (0.97) | ||||
CRP/ TNFα | CRP/ TNFα | 0.98 (0.98) | 0.80 (0.75) | 0.80 (0.76) | 0.98 (0.98) | ||||
IL-6/ TNFα | IL-6/TNFα | 0.98 (0.98) | 0.73 (0.50) | 0.75 (0.61) | 0.98 (0.97) | ||||
CRP/IL-6/ TNFα | CRP/IL-6/ TNFα | 0.98 (0.98) | 0.73 (0.50) | 0.75 (0.61) | 0.98 (0.97) | ||||
CRP/IL-6 | CRP/IL-6 | 0.98 (1.00) | 0.77 (0.50) | 0.77 (0.62) | 0.98 (1.00) | ||||
CRP/IL-6/ TNFα | CRP/IL-6/ TNFα | 0.98 (1.00) | 0.66 (0.43) | 0.70 (0.58) | 0.97 (1.00) | ||||
CRP/IL-6 | CRP/IL-6 | CRP/IL-6 | 0.98 (1.00) | 0.71 (0.47) | 0.73 (0.59) | 0.98 (1.00) | |||
CRP/ TNFα | CRP/ TNFα | CRP/ TNFα | 0.98 (0.98) | 0.75 (0.70) | 0.76 (0.72) | 0.88 (0.98) | |||
IL-6/ TNFα | IL-6/ TNFα | IL-6/ TNFα | 0.98 (1.00) | 0.63 (0.39) | 0.68 (0.57) | 0.97 (1.00) | |||
CRP/IL-6/ TNFα | CRP/IL-6/ TNFα | CRP/IL-6/ TNFα | 0.98 (1.00) | 0.63 (0.39) | 0.68 (0.57) | 0.97 (1.00) |
PPV = positive predictive value; NPV = negative predictive value.