Table 2

Changes in cardiorespiratory status with inhaled NO

MapFIO2OI
TreatedControlTreatedControlTreatedControl
09 (4-21)2-150 7 (3-12)0.45 (0.22-1.0)0.37 (0.21-0.72)7.9*** (1.6-46.7)3.1 (1.2-11.5)
30 minutes9 (4-21)** 7 (3-12)0.36 (0.21-1.0)0.37 (0.21-0.72)6.3 (1.2-45.7)3.2 (1.2-16.6)
1 hour9 (4-22)7 (3-12)0.36 (0.21-1.0)0.37 (0.21-0.86)6.7 (1.3-46.8)3.5 (1.1-14.6)
2 hours9 (4-19)6 (3-12)0.38 (0.21-1.0)0.33 (0.21-0.78)5.4 (1.3-39.6)3.0 (1.4-14)
4 hours9 (4-21)5 (3-11)0.36 (0.21-1.0)0.35 (0.22-0.83)5.3 (1.3-60.0)3.2 (2.1-105)
24 hours7 (0-21)5 (0-13)0.41 (0.21-1.0)0.31 (0.21-0.88)6.0 (1.5-28.8)5.0 (1.1-11.3)
48 hours6 (0-18)6 (0-11)0.37 (0.21-1.0)0.36 (0.21-1.0)5.2 (2.2-23.8)9.7 (2.1-23.2)
72 hours6 (0-21)6 (0-12)0.37 (0.21-1.0)0.32 (0.21-1.0)4.4 (1.6-46.7)4.1 (1.2-23.5)
96 hours4 (0-16)5 (0-14)0.32 (0.21-1.0)0.39 (0.21-0.92)3.5 (1.3-8.3)5.3 (1.2-25.3)
Day 70 (0-11)5 (0-11)0.30 (0.21-0.88)0.35 (0.21-0.77)9.5 (6.7-15.1)5.6 (2.9-12.2)
PaCO2MBPAT:RVET
TreatedControlTreatedControlTreatedControl
49 (28-74)44 (25-68)34 (29-48)41 (30-50)0.28 (0.16-0.41)0.30 (0.20-0.45)
48 (29-68)47 (28-70)34 (28-51)40 (34-60)0.30 (0.22-0.48)0.31 (0.21-0.43)
48 (27-69)46 (31-59)40 (25-55)40 (31-57)0.31 (0.18-0.46)0.29 (0.12-0.38)
47 (31-56)48 (33-59)38 (26-53)45 (30-60)0.28 (0.22-0.48)0.29 (0.18-0.39)
45 (26-68)45 (34-66)40 (30-46)40 (32-54)0.30 (0.18-0.43)0.28 (0.21-0.4)
43 (31-59)43 (30-71)38 (28-46)40 (32-52)0.32 (0.20-0.43)0.31 (0.21-0.41)
48 (29-53)43 (28-94)0.32 (0.20-0.41)0.31 (0.20-0.41)
49 (36-64)43 (29-95)0.30 (0.18-0.39)0.29 (0.24-0.41)
0.36 (0.20-0.39)0.32 (0.21-0.43)
0.29 (0.26-0.34)0.34 (0.25-0.45)
  • Values expressed as median (range).

  • MAP = mean airway pressure (cm H2O); FIO2 = fractional inspired oxygen concentration; PaCO2 = arterial partial pressure of CO2 (mm Hg); MBP = mean arterial blood pressure (mm Hg).

  • 2-150 p = 0.03 vs controls; ** p = 0.04 vscontrols; *** p = 0.02 vs controls.