PT  - JOURNAL ARTICLE
AU  - Bruckner, Marlies
AU  - Neset, Mattias
AU  - O'Reilly, Megan
AU  - Lee, Tze-Fun
AU  - Cheung, Po-Yin
AU  - Schmölzer, Georg M
TI  - Haemodynamic changes with varying chest compression rates in asphyxiated piglets
AID  - 10.1136/archdischild-2021-323271
DP  - 2023 Mar 01
TA  - Archives of Disease in Childhood - Fetal and Neonatal Edition
PG  - 200--203
VI  - 108
IP  - 2
4099  - http://fn.bmj.com/content/108/2/200.short
4100  - http://fn.bmj.com/content/108/2/200.full
SO  - Arch Dis Child Fetal Neonatal Ed2023 Mar 01; 108
AB  - Background Current neonatal resuscitation guidelines recommend that chest compressions (CCs) be delivered at a rate of 90/min. The aim of the study was to investigate the haemodynamic effects of different CC rates in a neonatal piglet model.Methods Six asphyxiated piglets were randomised to CC with rates of 60/min, 90/min, 120/min, 150/min and 180/min for 1 min at each rate. CCs superimposed with sustained inflations were performed with an automated CC machine.Results Six newborn piglets (age 0–3 days, weight 2.0–2.3 kg) were included in the study. Overall, there was a gradual increase in stroke volume, minimum and maximum rate of left ventricle pressure change (dp/dtmin and dp/dtmax), and carotid blood flow until CC rate of 150/min, with a level-off effect at a CC rate of 180/min. However, cardiac output continued to increase with the highest being at a CC rate of 180/min.Conclusion Rate of CC was associated with changes in haemodynamic parameters during cardiopulmonary resuscitation. CC rate of 150–180/min during CC resulted in the highest cardiac output and arterial blood pressure.Trial registration number Preclincialtrials.eu PCTE0000249.