RT Journal Article
SR Electronic
T1 Ductus arteriosus and the preterm brain
JF Archives of Disease in Childhood - Fetal and Neonatal Edition
JO Arch Dis Child Fetal Neonatal Ed
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP 96
OP 101
DO 10.1136/archdischild-2022-324111
VO 108
IS 2
A1 Valerie Y. Chock
A1 Shazia Bhombal
A1 Gabriel F.T. Variane
A1 Krisa P. Van Meurs
A1 William E. Benitz
YR 2023
UL http://fn.bmj.com/content/108/2/96.abstract
AB As the approach to the patent ductus arteriosus (PDA) in the preterm infant remains controversial, the potential consequences of a significant ductal shunt on the brain should be evaluated. In this population at high risk of adverse outcomes, including intraventricular haemorrhage and white matter injury, as well as longer-term neurodevelopmental impairment, it is challenging to attribute sequelae to the PDA. Moreover, individual patient characteristics including gestational age and timing of PDA intervention factor into risks of brain injury. Haemodynamic assessment of the ductus combined with bedside neuromonitoring techniques improve our understanding of the role of the PDA in neurological injury. Effects of various PDA management strategies on the brain can similarly be investigated. This review incorporates current understanding of how the PDA impacts the developing brain of preterm infants and examines modalities to measure these effects.