PT  - JOURNAL ARTICLE
AU  - Valerie Y. Chock
AU  - Shazia Bhombal
AU  - Gabriel F.T. Variane
AU  - Krisa P. Van Meurs
AU  - William E. Benitz
TI  - Ductus arteriosus and the preterm brain
AID  - 10.1136/archdischild-2022-324111
DP  - 2023 Mar 01
TA  - Archives of Disease in Childhood - Fetal and Neonatal Edition
PG  - 96--101
VI  - 108
IP  - 2
4099  - http://fn.bmj.com/content/108/2/96.short
4100  - http://fn.bmj.com/content/108/2/96.full
SO  - Arch Dis Child Fetal Neonatal Ed2023 Mar 01; 108
AB  - As the approach to the patent ductus arteriosus (PDA) in the preterm infant remains controversial, the potential consequences of a significant ductal shunt on the brain should be evaluated. In this population at high risk of adverse outcomes, including intraventricular haemorrhage and white matter injury, as well as longer-term neurodevelopmental impairment, it is challenging to attribute sequelae to the PDA. Moreover, individual patient characteristics including gestational age and timing of PDA intervention factor into risks of brain injury. Haemodynamic assessment of the ductus combined with bedside neuromonitoring techniques improve our understanding of the role of the PDA in neurological injury. Effects of various PDA management strategies on the brain can similarly be investigated. This review incorporates current understanding of how the PDA impacts the developing brain of preterm infants and examines modalities to measure these effects.