TY - JOUR T1 - Future of clinical trials in the delivery room: time for pragmatism JF - Archives of Disease in Childhood - Fetal and Neonatal Edition JO - Arch Dis Child Fetal Neonatal Ed SP - 102 LP - 105 DO - 10.1136/archdischild-2022-324387 VL - 108 IS - 2 AU - Colm Patrick Finbarr O'Donnell AU - Janneke Dekker AU - Mario Rüdiger AU - Arjan B te Pas Y1 - 2023/03/01 UR - http://fn.bmj.com/content/108/2/102.abstract N2 - Despite increased amounts of research, most of the evidence that supports treatment of newborns in the delivery room is rated ‘low’ rather than ‘high’ quality. This assessment stems largely from a lack of evidence from clinical trials. When trials have been performed, the evidence has often been downgraded due to enrolment of small or poorly representative samples, and for lack of blinding of caregivers and outcome assessors. Delivery room trials present particular challenges when obtaining consent, enrolling participants, taking measures to limit bias and identifying appropriate outcome measures. We hope our suggestions as to how future delivery room trials could be more pragmatic will inform the design of large studies that are necessary to allow clinical practice to evolve.Data sharing not applicable as no datasets generated and/or analysed for this study. ER -