PT - JOURNAL ARTICLE AU - Simon, Laure AU - Hadchouel, Alice AU - Arnaud, Catherine AU - Frondas-Chauty, Anne AU - Marret, Stéphane AU - Flamant, Cyril AU - Darmaun, Dominique AU - Delacourt, Christophe AU - Marchand-Martin, Laetitia AU - Ancel, Pierre Yves AU - Roze, Jean-Christophe TI - Growth trajectory during the first 1000 days and later overweight in very preterm infants AID - 10.1136/archdischild-2022-324321 DP - 2023 Mar 01 TA - Archives of Disease in Childhood - Fetal and Neonatal Edition PG - 149--155 VI - 108 IP - 2 4099 - http://fn.bmj.com/content/108/2/149.short 4100 - http://fn.bmj.com/content/108/2/149.full SO - Arch Dis Child Fetal Neonatal Ed2023 Mar 01; 108 AB - Objective To identify the characteristics of early life growth associated with later overweight or obesity (OWO) in very preterm population.Design Length, weight and body mass index (BMI) were prospectively recorded from three prospective, population-based cohorts with 5 years (Loire Infant Follow-up Team (LIFT), EPIPAGE2 (Etude EPIdémiologique sur les Petits Ages GEstationnels 2)) and 15 years (EPIPAGEADO, Etude EPIdémiologique sur les Petits Ages GEstationnels-Adolescents) of follow-up. Missing data were imputed.Setting Regional (LIFT), national (EPIPAGE2) and multiregional (EPIPAGEADO) cohorts in France.Patients Eligible infants born before 33 weeks of gestation in 1997 (EPIPAGEADO), between 2003 and 2014 (LIFT), and in 2011 (EPIPAGE2).Main outcome measures OWO was determined as BMI Z-score >85th percentile of the WHO reference curves at 5 years (LIFT, EPIPAGE2) and 15 years (EPIPAGEADO).Results In EPIPAGEADO, LIFT and EPIPAGE2, BMI Z-scores were known for 302 adolescents, 1016 children and 2022 children, respectively. In EPIPAGEADO, OWO was observed in 42 (13.9%, 95% CI 10.5 to 18.3) adolescents. In multivariable models, birthweight Z-score, increase in weight Z-score during neonatal hospital stay and increase in BMI between discharge and at 2 years of corrected age were positively associated with OWO at 15 years (adjusted OR (aOR)=3.65, 95% CI 1.36 to 9.76; aOR=3.82, 95% CI 1.42 to 10.3; and aOR=2.55, 95% CI 1.72 to 3.78, respectively, by Z-score), but change in length Z-score during neonatal hospital stay was negatively associated (aOR=0.41, 95% CI 0.21 to 0.78, p=0.007). These four associations with OWO assessed at 5 years were confirmed in the LIFT and EPIPAGE2 cohorts.Conclusions Change in length Z-score during hospitalisation, a putative proxy of quality of neonatal growth, was negatively associated with risk of later OWO when change in BMI between discharge and at 2 years was included in the multivariable model.Data are available upon reasonable request. Data are uploaded as supplementary document.