TY - JOUR T1 - Observational cohort study of use of caffeine in preterm infants and association between early caffeine use and neonatal outcomes JF - Archives of Disease in Childhood - Fetal and Neonatal Edition JO - Arch Dis Child Fetal Neonatal Ed DO - 10.1136/archdischild-2022-324919 SP - fetalneonatal-2022-324919 AU - Lisa Szatkowski AU - Sheeza Fateh AU - Janine Abramson AU - T'ng Chang Kwok AU - Don Sharkey AU - Helen Budge AU - Shalini Ojha Y1 - 2023/02/09 UR - http://fn.bmj.com/content/early/2023/02/08/archdischild-2022-324919.abstract N2 - Objective To quantify trends in caffeine use in infants born at <32 weeks’ gestational age (GA), and to investigate the effects of early vs late caffeine on neonatal outcomes.Study design Retrospective propensity score matched cohort study using routinely recorded data from the National Neonatal Research Database of infants born at <32 weeks’ GA admitted to neonatal units in England and Wales (2012–2020).Results 89% (58 913/66 081) of infants received caffeine. In 70%, caffeine was started early (on the day of birth or the day after), increasing from 55% in 2012 to 83% in 2020. Caffeine was given for a median (IQR) of 28 (17–43) days starting on day 2 (1–3) and continued up to 34 (33–34) weeks postmenstrual age.In the propensity score matched cohort of 13 045 pairs of infants, the odds of preterm brain injury (early caffeine, 2306/13 045 (17.7%) vs late caffeine, 2528/13 045 (19.4%), OR=0.89 (95% CI 0.84 to 0.95)) and bronchopulmonary dysplasia (BPD) (early caffeine, 4020/13 045 (32.8%) vs late caffeine, 4694/13 045 (37.7%), OR=0.81 (95% CI 0.76 to 0.85)) were lower in the group that received early caffeine compared with those who received it later.Conclusions Early use of caffeine has increased in England and Wales. This is associated with reduced risks of BPD and preterm brain injury. Randomised trials are needed to find the optimal timing of caffeine use and the groups of infants who will benefit most from early administration of caffeine.Data are available on reasonable request. Data are available on request. ER -