TY - JOUR T1 - Fantoms JF - Archives of Disease in Childhood - Fetal and Neonatal Edition JO - Arch Dis Child Fetal Neonatal Ed SP - 1 LP - 1 DO - 10.1136/archdischild-2022-325204 VL - 108 IS - 1 AU - Ben J Stenson Y1 - 2023/01/01 UR - http://fn.bmj.com/content/108/1/1.abstract N2 - Noa Fleiss and colleagues compare and contrast professional guidelines for the management of early onset neonatal sepsis from the UK and the USA. Although these are evidence based, the limitations of the evidence are such that several different approaches combining risk factors and clinical findings are supported that are associated with marked differences in the proportion of infants who are considered to require investigation and treatment. None is clearly superior and none will identify all affected infants before they become ill, so clinical vigilance is vital. The condition affects around one in a thousand infants and this makes reliable studies comparing the risks and benefits of different approaches very challenging. The wide range in proportions of infants treated is disruptive to families and costly for services and makes large scale prospective comparisons of these approaches a valuable aspiration. See page F10 Aneurin Young And colleagues provide a comprehensive … ER -