RT Journal Article SR Electronic T1 Effects of the SARS-CoV-2 pandemic on perinatal activity in Yorkshire and the Humber region during 2020: an interrupted time series analysis JF Archives of Disease in Childhood - Fetal and Neonatal Edition JO Arch Dis Child Fetal Neonatal Ed FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health SP 624 OP 629 DO 10.1136/archdischild-2021-323466 VO 107 IS 6 A1 Andrei Scott Morgan A1 Charlotte Bradford A1 Hilary Farrow A1 Elizabeth S Draper A1 Cath Harrison YR 2022 UL http://fn.bmj.com/content/107/6/624.abstract AB Objective To assess the impact of public health measures taken during the COVID-19 pandemic on perinatal health indicators.Design Interrupted time series analysis comparing periods of the pandemic with the previous 5 years.Setting Yorkshire and the Humber region, England (2015–2020).Main outcome measures Relative risk (RR) of stillbirth, extreme preterm (EPT, <27 weeks’ gestational age) delivery, hypoxic ischaemic encephalopathy (HIE) and meconium aspiration syndrome (MAS), antenatal transfer for threatened EPT delivery and postnatal transfer for EPT birth, HIE or MAS.Results Stillbirths fell from 3.7/1000 deliveries prepandemic to 2.9/1000 afterwards; EPT births decreased from 2.5/1000 to 1.8/1000 live births. Following adjustment, during the first lockdown there were decreased antenatal transfers (RR 0.74, 95% CI 0.57 to 0.94) with non-statistically significant increased stillbirth (RR 1.08, 95% CI 0.78 to 1.51) and decreased EPT admissions (RR 0.88, 95% CI 0.60 to 1.29). Over the entire pandemic period, antenatal transfer (RR 0.64, 95% CI 0.55 to 0.76) and EPT birth (RR 0.73, 95% CI 0.56 to 0.94) decreased; stillbirths showed non-statistically significant increases overall (RR 1.21, 95% CI 0.98 to 1.49) but with increasing trend through the pandemic (RR 1.11, 95% CI 1.00 to 1.22). No changes were seen for HIE, MAS, postnatal transfers or in subgroup analyses by ethnicity.Conclusions Lower rates of antenatal transfer and extreme preterm birth were identified, alongside an apparent increase in stillbirth over time. The findings provide evidence that effects on perinatal activity related to the pandemic changed over time.Data are available on reasonable request.