RT Journal Article SR Electronic T1 What’s New in the Management of Neonatal Early-Onset Sepsis? JF Archives of Disease in Childhood - Fetal and Neonatal Edition JO Arch Dis Child Fetal Neonatal Ed FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health SP fetalneonatal-2021-323532 DO 10.1136/archdischild-2021-323532 A1 Noa Fleiss A1 Kathleen Schwabenbauer A1 Tara M Randis A1 Richard A Polin YR 2022 UL http://fn.bmj.com/content/early/2022/05/25/archdischild-2021-323532.abstract AB The expert guidelines highlighted in this review provide an evidence-based framework for approaching at-risk infants and allow for a more limited and standardised approach to antibiotic use. While these guidelines have significantly reduced antibiotic utilisation worldwide, optimally each unit would individualise their approach to early onset sepsis (EOS) based on the neonatal population they serve and available resources. As advancements in EOS research continue and limitations with sepsis prediction tools are addressed, it is inevitable that our risk stratification and management guidelines will become more precise.