RT Journal Article
SR Electronic
T1 Preterm infant circulating sex steroid levels are not altered by transfusion with adult male plasma: a retrospective multicentre cohort study
JF Archives of Disease in Childhood - Fetal and Neonatal Edition
JO Arch Dis Child Fetal Neonatal Ed
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP fetalneonatal-2021-323433
DO 10.1136/archdischild-2021-323433
A1 Anders K Nilsson
A1 Gunnel Hellgren
A1 Ulrika Sjöbom
A1 Andreas Landin
A1 Henrik Ryberg
A1 Dirk Wackernagel
A1 David Ley
A1 Ingrid Hansen Pupp
A1 Matti Poutanen
A1 Claes Ohlsson
A1 Ann Hellstrom
YR 2022
UL http://fn.bmj.com/content/early/2022/02/28/archdischild-2021-323433.abstract
AB Objective To determine if plasma transfusions with male donor plasma to very preterm infants affect circulatory levels of sex steroids.Design and patients Retrospective multicentre cohort study in 19 infants born at gestational age <29 weeks requiring plasma transfusion during their first week of life.Setting Three neonatal intensive care units in Sweden.Main outcome measures Concentrations of sex steroids and sex hormone-binding globulin (SHBG) in donor plasma and infant plasma measured before and after a plasma transfusion and at 6, 12, 24 and 72 hours.Results The concentrations of progesterone, dehydroepiandrosterone and androstenedione were significantly lower in donor plasma than in infant plasma before the transfusion (median (Q1–Q3) 37.0 (37.0–37.0), 1918 (1325–2408) and 424 (303–534) vs 901 (599–1774), 4119 (2801–14 645) and 842 (443–1684) pg/mL), while oestrone and oestradiol were higher in donor plasma (17.4 (10.4–20.1) and 16.0 (11.7–17.2) vs 3.1 (1.1–10.2) and 0.25 (0.25–0.25) pg/mL). Median testosterone and dihydrotestosterone (DHT) levels were 116-fold and 21-fold higher in donor plasma than pre-transfusion levels in female infants, whereas the corresponding difference was not present in male infants. Plasma sex steroid levels were unchanged after completed transfusion compared with pre-transfusion levels, irrespective of the gender of the receiving infant. The SHBG concentration was significantly higher in donor than in recipient plasma (22.8 (17.1–33.5) vs 10.2 (9.1–12.3) nmol/L) before transfusion but did not change in the infants after the transfusion.Conclusions A single transfusion of adult male plasma to preterm infants had no impact on circulating sex steroid levels.Data are available upon request.